A review exploring biological activities of hydrazones

Verma, Garima; Marella, Akranth; Shaquiquzzaman, Mohammad; Akhtar, Mohd; Ali, Mazhar; Alam, Mohammad Mumtaz

doi:10.4103/0975-7406.129170

Cited by 283 publications

(45 citation statements)

References 81 publications

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“…Both BHBM and D0 are acylhydrazone compounds with the structure R 1 R 2 C = NNH 2 ( Fig. 1 ) ( 30 – 32 ). Hydrazone molecules have been shown to exert diverse biological functions, including antibacterial, antifungal, antiviral, antiparasitic, anticancer, and antidepressant effects ( 33 – 36 ), but these activities are linked to specific structures of hydrazones, which we can readily modify (data not shown), potentially increasing their antifungal activity.…”

Section: Discussionmentioning

confidence: 99%

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Mor

Rella

Farnoud

et al. 2015

mBio

127

109

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Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi. In this study, we screened a synthetic drug library for compounds that target the synthesis of fungal, but not mammalian, GlcCer and found two compounds [N′-(3-bromo-4-hydroxybenzylidene)-2-methylbenzohydrazide (BHBM) and its derivative, 3-bromo-N′-(3-bromo-4-hydroxybenzylidene) benzohydrazide (D0)] that were highly effective in vitro and in vivo against several pathogenic fungi. BHBM and D0 were well tolerated in animals and are highly synergistic or additive to current antifungals. BHBM and D0 significantly affected fungal cell morphology and resulted in the accumulation of intracellular vesicles. Deep-sequencing analysis of drug-resistant mutants revealed that four protein products, encoded by genes APL5, COS111, MKK1, and STE2, which are involved in vesicular transport and cell cycle progression, are targeted by BHBM.

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Section: Discussionmentioning

confidence: 99%

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Mor

Rella

Farnoud

et al. 2015

mBio

127

109

View full text Add to dashboard Cite

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“…Despite the fact that acylhydrazone derivatives are rapidly metabolized, this motif is encountered in several approved drugs (e.g., nifuroxazide and dantrolene) [24] and drug candidates [25][26][27]. The facile synthetic availability of acylhydrazone derivatives, which allows furnishing congeneric series of compounds with distinct physico-chemical properties and bioactivities, makes it a promising scaffold in the drug discovery field [28][29][30]. Herein, we describe the synthesis of novel derivatives and the determination of their in vitro and in cellulo ability to bind to G4 of EBNA1 mRNA, as well as their effect on NCL-mediated GArdependent limitation of EBNA1 expression and antigen presentation.…”

Section: Introductionmentioning

confidence: 99%

Novel cationic bis(acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA

Reznichenko

Quillévéré

Martins

et al. 2019

European Journal of Medicinal Chemistry

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…These complexes show oxidase biometric catalytic activity, anticancer and antimicrobial activities [6][7][8][9][10][11]. The study of Schiff bases and their complexes has become a focal point of interest for chemists in recent years, not only for their several structural features, but due to their potential application in various fields [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectroscopic Investigations of Schiff Bases Transition Metal Complexes of Copper(II), Cobalt(II) and Nickel(II)

Rai¹,

Kumari²,

Rai³

2017

Asian J. Chem.

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This work presents an experimental and theoretical study on complexes of copper(II), cobalt(II) and nickel(II) with Schiff base ligand 3-propyl-(N-o-toluidine)quinazoline semicarbazone (PTQS). The spectroscopic properties of the complexes have been investigated by IR and electronic spectra. The molecular geometry of the complexes have been proposed on the basis of elemental analyses, molar mass and magnetic susceptibility. It is suggested that the ligand PTQS acts in a bidentate manner and coordination proposes with azomethine N and carbonyl oxygen atom of semicarbazone moiety. The remaining coordination sites are occupied by negative ions such as Cl − . The geometry of complexes was assigned to be octahedral.

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A review exploring biological activities of hydrazones

Cited by 283 publications

References 81 publications

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Novel cationic bis(acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA

Synthesis and Spectroscopic Investigations of Schiff Bases Transition Metal Complexes of Copper(II), Cobalt(II) and Nickel(II)

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