Synthesis of Biphasic Calcium Phosphate by Hydrothermal Route and Conversion to Porous Sintered Scaffold

Abstract

Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) was successfully synthesized by new hydrothermal route using β-TCP as precursor. The X-ray diffraction analysis of as-synthesized powder indicated that β-TCP had been transformed into HA phase and amount of HA formed gradually increased with prolonged time. The results revealed that the recent technique may be able to control the composition of the obtained BCP which would influence the bioresorbability. Porous body of BCP was prepared by impregnation of polymeric sponge template with the slurry of the powder followed by sintering. The X-ray diffraction of porous product revealed that the composition of β-TCP increased after sintering indicating that HA had been decomposed. Porous BCP obtained from the recent technique possessed both macro and micropores structure which are useful for rapid tissue formation. Besides, the recent porous fabrication technique yielded porous BCP which preserved the sponge template morphology, enabling it to fabricate porous material with controlled pores structure.

Cytotoxicity and mechanical properties of biphasic calcium phosphate scaffold from Tegilarca granosa due to its composition

“…Table 3 and Figure 2 Similar research also proves that with increasing length of hydrothermal time there is an increase in the percentage of HA followed by a decrease in the TCP peak and an increase in the HA peak in XRD examination. 22 On the other hand, at a hydrothermal time of 12 hours the HA content was found to be lower and the TCP content was higher than at a hydrothermal time of 6 hours and 9 hours, namely 72% and 21%. These results prove that in this study the analysis, most HA will convert into TCP after the sintering process at a temperature of 1000°C.…”

“…The results of this research indicate that the change in TCP to HA which occurs gradually and over a certain length of time in the hydrothermal reaction makes it potential and probable to control the composition of BCP and HA by regulating the length of the hydrothermal time. Apart from the length of hydrothermal time, the hydrothermal temperature factor also influences the formation of HA and TCP.Research that was conducted using a hydrothermal temperature of 160˚C shows that the percentage of HA increases meanwhile the percentage of TCP decreases results in increasing hydrothermal time of 4h, 24h, 48h, and 72h 22. At a temperature of 900˚C HA can change into Tricalsium phosphate (TCP) and Tetracalcium phosphate (TTCP).…”