Biocompatibility Issues of Biomaterials

Asadi

J of Applied Polymer Sci

2018

Bioactive wound dressings from poly(vinyl alcohol) (PVA) and zein nanoparticles (NPs) loaded with diclofenac (DLF) were prepared successfully by the single jet electrospinning method. DLF‐loaded zein NPs with an average diameter of ∼228 nm were prepared using anti‐solvent precipitation method. The formulation of zein:DLF 1:1 exhibited optimum encapsulation efficiency of 47.80%. The NPs were characterized by dynamic light scattering, zeta‐potential measurement, and differential scanning calorimetry. In vitro, drug release profiles of the DLF‐loaded zein NPs, and PVA–zein NPs were also studied within 120 h and showed the release efficiency of nearly 80% from zein NPs. A more controlled release of DLF was achieved by embedding the zein NPs in the PVA nanofibers. Fourier transform infrared spectroscopy was used to analyze possible interactions between different components of the fabricated dressings. The mechanical properties of the developed dressings were also evaluated using uniaxial tensile testing. Young's modulus (E) of the dressings decreased after inclusion of zein NPs within the PVA nanofibers. Moreover, fibroblast culturing experiments proved that the composite dressings supported better cell attachment and proliferation compared to PVA nanofibers, by exhibiting moderate hydrophilicity. The results suggested that the electrospun composite dressing of PVA nanofibers and zein NPs is a promising topical drug‐delivery system and have a great potential for wound healing application. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46643.

Section: Fibroblast Adhesion and Proliferationmentioning

confidence: 99%

Zein nanoparticle‐embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti‐inflammatory diclofenac

Asadi

J of Applied Polymer Sci

2018

“…Several studies have applied various biomaterials and technologies to establish anti-adhesion barriers [ 26 , 27 , 37 , 38 , 71 , 72 ]. These anti-adhesion biomaterials have excellent biocompatibility and biodegradability [ 73 , 74 ] and can be classified as either natural or synthetic polymers.…”

Section: Polymers As Materials For Anti-adhesion Barriersmentioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

Surgery is performed to treat various diseases. During the process, the surgical site is healed through self-healing after surgery. Post-operative or tissue adhesion caused by unnecessary contact with the surgical site occurs during the normal healing process. In addition, it has been frequently found in patients who have undergone surgery, and severe adhesion can cause chronic pain and various complications. Therefore, anti-adhesion barriers have been developed using multiple biomaterials to prevent post-operative adhesion. Typically, anti-adhesion barriers are manufactured and sold in numerous forms, such as gels, solutions, and films, but there are no products that can completely prevent post-operative adhesion. These products are generally applied over the surgical site to physically block adhesion to other sites (organs). Many studies have recently been conducted to increase the anti-adhesion effects through various strategies. This article reviews recent research trends in anti-adhesion barriers.

Journal of Physical Chemistry and Functional Materials

“…A Biomaterial can adapt itself to the chemical reaction in the human body [71,72]. Smart Biomaterials especially shape memory alloys can be used inside the human body as implants, which have two main superior behaviors including bio functionality and biocompatibility [73][74][75].…”

Section: Biocompatibilitymentioning

confidence: 99%

A Review on NiTiCu Shape Memory Alloys: Manufacturing and Characterizations

QADIR

Mohammed

Kök

et al. 2021

ARTICLE INFOShape memory alloys have the thermoelastic phase transformation, known as shape memory characteristics, which make them be used in wide technological applications compared to other alloys. Ni-Ti based SMAs compared to the other families have more applications especially in the biomedical field since they have high biocompatibility, high strain recovery, flexibility, and antirust. In this work, the studies conducted for NiTiCu SMAs were reviewed. Additionally, different manufacturing techniques used by researchers have been explained. Different characteristics of the alloys have been clarified and compared with some other families.