Synthesis of articular cartilage‐inspired branched polyelectrolyte polymer for enhanced lubrication

Wang, Yixin; Wan, Li; Sun, Yulong; Zhang, Hongyu

doi:10.1049/bsbt.2020.0004

Cited by 1 publication

(5 citation statements)

References 29 publications

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“…The signals at 3.20, 3.65, 4.05, 4.18, and 4.26 ppm are attributed to the protons of the MPC moiety, and the peaks at 2.64, 2.74, 2.85, 2.98, 3.23, and 3.43 ppm belong to the protons of the PEI unit. The weight percentage of PMPC in the PEI-PMPC polymer is calculated to be about 16.64% according to the method reported in previous studies. , Moreover, the FTIR spectrum of the polymer is shown in Figure C, with the absorption bands of CO, PO, P–O–C, and P–O assigned at 1725, 1228, 1064, and 967 cm –1 , respectively. In addition, the absorption peaks from approximately 3000 to 3700 cm –1 are ascribed to hydroxyl and amino groups.…”

Section: Resultsmentioning

confidence: 94%

“…The weight percentage of PMPC in the PEI-PMPC polymer is calculated to be about 16.64% according to the method reported in previous studies. 30,31 Moreover, the FTIR spectrum of the polymer is shown in Figure 1C, with the…”

Section: Discussionmentioning

confidence: 99%

“…The PEI-PMPC polymer was synthesized according to the similar method as previously reported, where the MPC monomer was attached to the amino groups on the side chains of PEI via TBHP-induced grafting polymerization. , Briefly, PEI (25 kDa, 0.53 g, 0.021 mmol) and MPC (0.345 g, 1.17 mmol) were adequately dissolved in a round-bottom flask with deionized water (15 mL). TBHP (10 μL) was added dropwise to the solution under magnetic stirring, and the solution was bubbled with nitrogen for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In our previous study, we successfully synthesized a polyelectrolyte polymer (PEI-PMPC) employing PEI and the monomer of PMPC based on tert-butyl hydroperoxide (TBHP)-initiated grafting polymerization and preliminarily investigated its lubrication performance. 30 However, it still remains a challenge to reliably anchor the PEI-PMPC polymer to the PU surface. Bioinspired from catecholamine chemistry, polydopamine (PDA) with good biocompatibility has been widely employed for surface modification of different biomaterials, and the benzoquinone formed by oxidation of dopamine can further react with the remaining amino groups in PEI-PMPC.…”

Section: Introductionmentioning

confidence: 99%

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Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

Zhao

Qian

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants.

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Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%