Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

Abstract

Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants.

A dynamic hard domain-induced self-healable waterborne poly(urethane/acrylic) hybrid dispersion for 3D printable biomedical scaffolds

“…In vitro, the biocompatibility of the various concentrations of SWPUA 2 enables cellular adhesion and proliferation of L929 cells, according to investigations on cellular viability and proliferation. 36 A UV-curable SWPUA/GelMA/gelatin-based ink for biomedical scaffold preparation…”

Broad-Spectrum Antimicrobial Polymer-Coated Fabrics via Commodity Polystyrene Upcycling

“…While this latest pandemic was caused by a virus, infections by pathogenic bacteria and fungi represent no less of a threat due to the emergence of multidrug resistance (MDR). , This critical threat to human health posed by MDR “superbugs” has been attributed to our overuse and misuse of antibiotics and antifungals in past decades. To overcome this problem, functional materials such as antimicrobial peptides, synthetic cationic polymers, − antimicrobial nanomaterials, composites, − and coatings − have been explored. While effective, antimicrobial peptides tend to be costly and susceptible to enzymatic degradation .…”