Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity

Elsharif, Asma M.; Youssef, Tamer E.; Al-Jameel, Suhailah S.; Mohamed, Hanan H.; Ansari, Mohammad Azam; Rehman, Suriya; Akhtar, Sultan

doi:10.1155/2019/5964687

Cited by 6 publications

(5 citation statements)

References 19 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, an enhanced activity was found against E. coli as compared to S. aureus ; this slight difference could be attributed to the varying cell wall composition among these bacterial strains [41]. In some earlier studies, various metal-substituted NPs, like copper, zinc, nickel, and manganese, were recorded as possessing antibacterial activities [42,43], although the antibacterial activity of the current combination of Mn 0.5 Zn 0.5 Sm x Eu x Fe 1.8−2x O 4 (0.01 ≤ x ≤ 0.05) NPs is the first of its kind to the best of the author′s knowledge.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities

et al. 2019

Self Cite

View full text Add to dashboard Cite

Manganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn0.5Zn0.5SmxEuxFe1.8−2xO4 (0.01 ≤ x ≤ 0.05) nanoparticles (NPs) by using the hydrothermal approach. The structure and surface morphology of the products were determined by X-ray powder diffraction (XRD), transmission electron and scanning electron microcopies (TEM and SEM), along with energy dispersive X-ray spectroscopy (EDX). We evaluated the impact of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 NPs on both human embryonic stem cells (HEK-293) (normal cells) and human colon carcinoma cells (HCT-116) (cancerous cells). We found that post-48 h of treatment of all products showed a significant decline in the cancer cell population as revealed by microscopically and the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium (MTT) assay. The inhibitory concentration (IC50) values of the products ranged between 0.75 and 2.25 µg/mL. When tested on normal and healthy cells (HEK-293), we found that the treatment of products did not produce any effects on the normal cells, which suggests that all products selectively targeted the cancerous cells. The anti-bacterial properties of the samples were also evaluated by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays, which showed that products also inhibited the bacterial growth.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Following the MIC analysis, an aliquots of 100 µl from wells with no visible bacterial growth (i.e., below MIC value) were inoculated on MHA plates for 24 h at 37 0 C. MBC was defined as the concentration that killed 99.99% of bacteria [ [32] ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis of indole-based oxadiazoles and their interaction with bacterial peptidoglycan and SARS-CoV-2 main protease: In vitro, molecular docking and in silico ADME/Tox study

Ansari

Taha

Uddin

et al. 2022

Journal of Saudi Chemical Society

Self Cite

View full text Add to dashboard Cite

“…After that, the samples were fixed on the aluminum stubs and left for complete drying, and then the samples were coated with gold and finally, the effects of NSFs on the morphology of MRSA and C. albicans were observed under a scanning electron microscope at an accelerating voltage of 20 kV. 24 …”

Section: Methodsmentioning

confidence: 99%

Sol–Gel Synthesis of Dy-Substituted Ni0.4Cu0.2Zn0.4(Fe2-xDyx)O4 Nano Spinel Ferrites and Evaluation of Their Antibacterial, Antifungal, Antibiofilm and Anticancer Potentialities for Biomedical Application

Ansari¹,

Akhtar²,

Rauf³

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

Background The constant rise of microbial biofilm formation and drug resistance to existing antimicrobial drugs poses a significant threat to community health around the world because it reduces the efficacy and efficiency of treatments, increasing morbidity, mortality, and health-care expenditures. As a result, there is an urgent need to develop novel antimicrobial agents that inhibit microbial biofilm formation. Methods The [Ni 0.4 Cu 0.2 Zn 0.4 ](Fe 2-x Dy x )O 4 (x≤0.04) (Ni-Cu-Zn) nano spinel ferrites (NSFs) have been synthesized by the sol–gel auto-combustion process and were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX) and transmission electron microscopy (TEM). The antimicrobial, antibiofilm and antiproliferative activities of Ni-Cu-Zn NSFs were also examined. Results The XRD pattern confirms the secondary phase DyFeO 3 and Fe 2 O 3 for substituted Dy 3 + samples, and the crystallite size ranged from 10 to 19 nm. TEM analysis of NSFs revealed that the particles were cube-shaped and 15nm in size. NSFs exhibited significant antimicrobial, antibiofilm and antiproliferative activity. At concentration of 1 mg/mL, it was found that the NSFs (ie, x=0.0, x=0.01, x=0.02, x=0.03 and x=0.04) inhibit biofilm formation by 27.6, 26.2, 58.5, 33.3 and 25% for methicillin-resistant Staphylococcus aureus (MRSA) and 47.5, 43.5, 48.6, 58.3 and 26.6% for Candida albicans , respectively. SEM images demonstrate that treating MRSA and C. albicans biofilms with NSFs significantly reduces cell adhesion, colonization and destruction of biofilm architecture and extracellular polymeric substances matrices. Additionally, SEM and TEM examination revealed that NSFs extensively damaged the cell walls and membranes of MRSA and C. albicans . Huge ultrastructural alteration such as deformation, disintegration and separation of cell wall and membrane from the cells was observed, indicating significant loss of membrane integrity, which eventually led to cell death. Furthermore, it was observed that NSF inhibited the cancer cell growth and proliferation of HCT-116 in a dose-dependent manner. Conclusion The current study demonstrated that the synthesized Ni-Cu-Zn NSFs could be used to develop potential antimicrobial surface coatings agents for a varieties of biomedical-related materials and devices in order to prevent the biofilms formation and their colonization. Furthermore, the enhanced antiproliferative properties of manufactured SNFs suggest a wide range of biomedical applications.

show abstract

Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity

Cited by 6 publications

References 19 publications

Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities

Synthesis of Mn0.5Zn0.5SmxEuxFe1.8−2xO4 Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities

Synthesis of indole-based oxadiazoles and their interaction with bacterial peptidoglycan and SARS-CoV-2 main protease: In vitro, molecular docking and in silico ADME/Tox study

Sol–Gel Synthesis of Dy-Substituted Ni0.4Cu0.2Zn0.4(Fe2-xDyx)O4 Nano Spinel Ferrites and Evaluation of Their Antibacterial, Antifungal, Antibiofilm and Anticancer Potentialities for Biomedical Application

Contact Info

Product

Resources

About