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The monomeric octaethylhexyl-and tetra-tert-butyl-substituted phthalocyanines 3 and 12 with axial acetylacetonate as ligands were synthesized and characterized, in order to compare their optical limiting properties with the state-ofthe-art molecule [tetra-(tert-butyl)phthalocyaninato]indium chloride (tBu) 4 PcInCl (1a) and the phthalocyanines 1b−f. In addition, the trimer 17 was also synthesized (as a mixture of

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Hay synthesis of a novel series of symmetrically tetra-substituted thiophenyl zinc(II)phthalocyanines (RS)ZnPcs 4a-c was reported. Their novel 4-thiophenyl-phthalonitriles precursors 3(a-c) were synthesized from their substituted thiophenols 2(a-c). They were screened for their in-vitro antitumor activity on Human lung adenocarcinoma (A549), human breast adenocarcinoma (MCF-7) and hepatocellular carcinoma in comparison with healthy normal cells (human fibroblast cells). Preliminary study of the structure-activity relationship showed that electronic factors in the trifluoromethyl moiety that attached to the ZnPc skeleton had a magnificent effect on the antitumor activity of the newly synthesized (RS)ZnPcs 4a-c. More interestingly, the ZnPc 4c showed promising anticancer activity against the tested human cancer cell lines. The detailed synthesis, characterization and biological screening data were reported.

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