Synthesis of 6’ H-spiro(indene-2,2’ -[1,3]oxathiane)-1,3,5’ -triones

Recent applications of ninhydrin in multicomponent reactions

“…Besides nitrogen-based nucleophiles, its C-2 position is reactive towards various carbon-, oxygen-and sulphur-based nucleophiles, resulting in C-C, C-O and C-S bonds, respectively. [7][8][9][10][11][12][13][14] Due to its unique chemical structure and capability to form a dehydrated triketone analogue, it has the potential to act as a building block in diverse organic synthesis strategies. [15][16][17][18][19][20][21] Furthermore, ninhydrin has special applications in the eld of uorescence.…”

DABCO Catalyzed Synthesis of β‐Hydroxy Ketones Derived from α‐Methyl Ketones and Ninhydrin under Microwave Irradiations

“…[1] Ninhydrin have highly activated carbonyl at C-2 position which readily reacts with carbon, nitrogen, oxygen, and sulfur nucleophiles which results in the formation of CÀ C, CÀ N, CÀ O and CÀ S bonds respectively. [2][3][4][5][6] There are ample of name reactions for CÀ C bond construction but among them cross aldol condensation are most widely used. Isatin undergoes cross aldol reaction with ketones to give many biologically and pharmaceutically active products .…”

“…Ninhydrin is a privileged structural constituent which is involved as intermediates for the synthesis of an extensive range of pharmaceutically and biologically active compounds . [1] Ninhydrin have highly activated carbonyl at C‐2 position which readily reacts with carbon, nitrogen, oxygen, and sulfur nucleophiles which results in the formation of C−C, C−N, C−O and C−S bonds respectively . There are ample of name reactions for C−C bond construction but among them cross aldol condensation are most widely used.…”