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In the present study, a facile, efficient, and environmentally benign approach for secondary amide transamidation by using tert-butyl hydroperoxide (TBHP) as a radical initiator has been developed. The method involves a two-step approach in which the first step is the CÀ N bond activation via N-functionalization with Boc to weaken the amide CÀ N bond by making amide non-planar and electronically destabilized. In the second step, an N-Bocactivated secondary amides undergoes transamidation with the various primary, secondary, aliphatic, aromatic, as well as the sterically hindered amines, using TBHP as a radical initiator to give the products in good to excellent yields. TBHP is easily available, inexpensive, and an environmentally friendly radical initiator. A broad substrate scope with extensive functional group tolerance, metal and catalyst-free approach, and operational simplicity are the important characteristics of the present protocol.

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Microwave induced an efficient, green and rapid protocol for the synthesis of 2‐substituted‐2‐hydroxyindan‐1,3‐dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4‐diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal‐free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol.

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