Synthesis of 3-hydroxy-2H-iminolactones and 3-hydroxy-2H-pyrrol-2-ones from reaction between isocyanides and methyl-2-acetylacetoacetate

Abstract

A one pot synthesis of new lactam derivatives is reported from reactions between alkyl or aryl isocyanides and methyl 2-acetylacetoacetate in good yields.

Three-Component Reaction between alkyl(aryl) Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of Ethyl Trifluoroacetate

“…20,21 There are a number of reports of iminolactones synthesis. [22][23][24] In continuation of our previous works on IMCRs, [25][26][27][28][29][30][31][32][33] we now report the result of our investigation of the reaction between alkyl(aryl) isocyanides 1 and dialkyl acetylenedicarboxylates 2 in the presence of ethyl trifluoroacetate 3 in refluxing CH 2 Cl 2 .…”