Three-Component Reaction between alkyl(aryl) Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of Ethyl Trifluoroacetate

Isocyanide-based multicomponent reactions in the synthesis of heterocycles

“…-functionalized furan-based heterocycles, dialkyl 5-[alkyl(aryl)imino]-2-ethoxy-2-(trifluoromethyl)-2,5-dihydrofuran-3,4-dicarboxylates, 201 were synthesized via un-catalyzed multicomponent reaction of dialkyl acetylenedicarboxylates 188, isocyanides 87 and ethyl trifluoroacetate 200 (Scheme 48)188 . High yields, mild reaction conditions, broad substrate scope were the advantages of this approach.…”

Fe(CO)5Catalyzed [2+2+1] Cycloaddition of Alkyne, Carbodiimide and CO for the Synthesis of 5-Iminopyrrolones

“…have reported the synthesis of various 5‐iminopyrrolone derivatives from palladium‐catalyzed and CsF‐promoted annulation reaction of bromoalkynes and isocyanides . 5‐iminopyrrolone derivatives were also synthesized by the reactions of isocyanides and dialkyl acetylenedicarboxylates with phenyl isocyanate . In this communication, we report a new methodology for the synthesis of various 5‐iminopyrrolones, which involves [2+2+1] cycloaddition of a terminal alkyne, a carbodiimide and CO, in presence of Fe(CO) 5 .…”

Synthesis of 1‐(Cyclohexylamino)‐2‐(aryl)pyrrolo[1,2‐a]quinoline‐3‐carbonitrile Derivatives Using a Mild, Four‐Component Reaction

“…Because of the aforementioned finding and as a part of our ongoing research program on the IMCRs , we report herein the synthesis of substituted 1‐(cyclohexylamino)‐2‐(aryl)pyrrolo[1,2‐a]quinoline‐3‐carbonitrile derivatives 5 by a four‐component condensation reaction (Scheme ).…”

“…Because of the aforementioned finding and as a part of our ongoing research program on the IMCRs [24][25][26][27][28][29][30][31], we report herein the synthesis of substituted 1-(cyclohexylamino)-2-…”