Synthesis of 3-Amino-6,7-Dihydroferroceno[a]Quinolizin-4-One Derivatives via the Reaction of 3,4-Dihydroferroceno[c]Pyridines with Azlactones

Easy Route to New Fused Dihydroisoquinoline-Naphthyridinone Frameworks

“…32 It includes an enamine attack on the activated double bond of azlactone, followed by the closure of the pyridone ring. 32,33 At the same time, 2-aryl-substituted 3-amino-6,7-dihydro-4H-pyrido[2,1-a]isoquinolin-4-ones are still obtained in low yield by oxidation of dihydro derivatives 2. 30 In order to study an alternative approach to the synthesis of 2-aryl-3-amino-6,7-dihydro-4H-pyrido[2,1-a]isoquinolin-4-ones 10a-f, we synthesized 3,4-dihydroisoquinolines 8a-e by a three-component condensation of substituted benzenes with isobutyric aldehyde, and acetonitrile, 32,34,35 as well as compound 8f by the Bischler-Napieralski reaction from N- (3,4-dimethoxyphenethyl)acetamide.…”

“…36 4-(3-Oxoisobenzofuran-1(3H)-ylidene)oxazol-5(4H)-one (7) was synthesized from hippuric acid and phthalic anhydride by heating in Ac 2 O. 33 Heating of azlactone 7 with compounds 8a-f in acetonitrile for 5 hours afforded pyridoisoquinolines 10a-f in 74-83% yields (Scheme 1). This is the first example of the reaction of 4-(3-oxoisobenzofuran-1(3H)-ylidene)oxazol-5(4H)-one (7) with enamines.…”

“…32 It includes an enamine attack on the activated double bond of azlactone, followed by the closure of the pyridone ring. 32 33 At the same time, 2-aryl-substituted 3-amino-6,7-dihydro-4 H -pyrido[2,1- a ]isoquinolin-4-ones are still obtained in low yield by oxidation of dihydro derivatives 2 . 30…”

“…36 4-(3-Oxoisobenzofuran-1(3 H )-ylidene)oxazol-5(4 H )-one ( 7 ) was synthesized from hippuric acid and phthalic anhydride by heating in Ac 2 O. 33…”

Bioinformatic Study of Ziziphus Jujuba (Rhamnaceae) in Preventing the Growth of Breast Cancer

“…This preventive approach, if widely implemented by international agencies, governments, industry, health professionals, consumers, and consumer advocacy groups, could reduce the global incidence of cancer by 10-20% within 10-25 years [ 12,13] One of the plants that can prevent the growth of breast cancer is Ziziphus jujube (Rhamnaceae) bidara plant [ 14,15,16 ] . The bidara plant has many useful ingredients including protein, calcium, iron, magnesium, vitamins, active compounds such as flavonoids, carotenoids, alkaloids, phenols, quercetin, methyl esters, terpenoids, saponins, and so on [17,18,19,20].…”