Synthesis of 2-(diethylamino)ethyl methacrylate-based polymers

Barral, Silvia; Guerreiro, António; Villa‐García, María A.; Rendueles, Manuel; Dı́az, Mario; Piletsky, Sergey A.

doi:10.1016/j.reactfunctpolym.2010.08.003

Cited by 16 publications

(3 citation statements)

References 51 publications

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“…[34] Physical parameters such as stirring speed, reaction time, temperature, and reactor dimension whereas chemical parameter such as crosslinker (hydrophilic/hydrophobic), porogen (solvating/non-solvating), and their concentration significantly controls the surface area. However, crosslinker is the major parameter which attributes to variation in the surface area of polymer.…”

Section: Effect Of Crosslinkersmentioning

confidence: 99%

Design and synthesis of cauliflower-shaped hydroxyl functionalized core-shell polymer

Mane

Ponrathnam

Chavan

2015

Designed Monomers and Polymers

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Conventional crosslinked polymers and homopolymers both have their own limitations. As a result, core-shell polymer was synthesized to obtain cauliflower-shaped and highly hydroxyl functionalized polymer. For the core, acrylate-based copolymers were synthesized by varying crosslinkers and porogens at different crosslink density. Owing to high surface area (554 m 2 /g), poly(MMA-co-DVB) was used as a core and low-molecular weight (24,600 g/mol) poly(GMA) was used as a shell in core-shell approach. Average particle sizes of the core polymers were in the range of 15-75 μm. In order to evaluate reactivity efficiency of core-shell polymer, hydroxyl content was evaluated with a value of 3.97 mmol/ g. Importantly, hydroxyl content demonstrated the successful increase in reactive sites of the core-shell polymer over conventional crosslinked hydroxyl polymer. Notably, synthesized core-shell polymer has more surface area and pore volume which substantially attributes for better polymer efficiency during application. Scanning electron microscopy images revealed the spherical, uniform, and slightly conglomerated properties of core-shell polymer. Due to higher reactivity, insolubility, and more surface area of hydroxyl functionalized core-shell polymer, its use become inevitably essential.

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Section: Effect Of Crosslinkersmentioning

confidence: 99%

Design and synthesis of cauliflower-shaped hydroxyl functionalized core-shell polymer

Mane

Ponrathnam

Chavan

2015

Designed Monomers and Polymers

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“…The reason for this is the versatility of acrylic monomers, which indicates their adaptability. In recent studies, this turned out to be urgent for amino methacrylate derivatives in areas such as waste water treatment, biochemical sensor and protein purification [2]. Due to their physical properties, acrylates are used in medicine, orthopedics, tooth and filling materials, drug delivery systems, biochemical sensors and soft tissue studies [3].…”

Section: Introductionmentioning

confidence: 99%

The physical studies and interaction with anti-apoptotic proteins of 2-(bis(cyanomethyl)amino)-2-oxoethyl methacrylate molecule

Yalçın¹,

Sas²,

Çankaya³

et al. 2019

Condens. Matter Phys.

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In this work 2-(bis(cyanomethyl)amino)-2-oxoethyl methacrylate (CMA2OEM) molecule has been characterized theoretically. First, the potential energy surface has been calculated to find the lowest energy state of the molecule. After the most stable state of the molecule, Mulliken atomic charge and nonlinear-optical properties were investigated. Also in the study, binding poses of CMA2OEM molecule and anti-apoptotic proteins, such as BCL-2, BCL-w, MCL-1, AKT1 and BRAF were investigated. The molecular docking results showed that the most stable complex was obtained with this molecule and BRAF protein. The molecular docking results showed that the most stable complex was obtained with this molecule and serine/threonine-protein kinase protein.This study suggested that molecular docking approach may be a potential tool to identify the hydrogen bond interactions in order to treat a disease. Finally, this new ligand could pave the way to experimental studies.

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“…Conversely, synthetic polymeric nanoparticles (NPs) with an intrinsic affinity for specific peptides and proteins represent a new research tool for biological and biomedical research and may assist with the treatment of many common hereditary diseases by removing antibodies with specificity. 4,5 NPs offer a robust matrix, less susceptible to the factors that would render biological matter ineffective, such as high temperature and variations in pH or storage conditions. Because of their relatively low cost and high stability, polymer NPs appear to have a clear advantage over antibodies.…”

mentioning

confidence: 99%

Combinatorial screening of polymer nanoparticles for their ability to recognize epitopes of AAV‐neutralizing antibodies

Piletska

Piletsky

et al. 2019

J of Molecular Recognition

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A library of 17 nanoparticles made of acrylate and methacrylate copolymers is prepared, characterized, and screened against six epitopes of adeno‐associated viruses (AAV)‐neutralizing antibodies to assess their affinity and specificity. Peptide epitopes are immobilized onto the surface of glass beads, packed in filtration microplates, and incubated with fluorescein‐labelled nanoparticles. Following intense washing, the affinity of nanoparticles to immobilized epitopes is assessed by measuring the fluorescence of captured nanoparticles. The results show that polar monomers, acrylic acid in particular, have a positive impact on polymer affinity towards all peptides used in this study. The presence of hydrophobic monomers, on other hand, has a negative impact on polymer binding. The composition of peptides used in this study has no noticeable impact on the affinity of synthesized nanoparticles. The affinity of nanoparticles with the highest affinity to peptide targets does not exceed millimolar level. Overall, it is found that the synthesized library showed modest affinity but lacked specificity, which should be further “tuned,” for example, by using molecular imprinting to achieve an acceptable level of affinity and specificity for practical application.

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Synthesis of 2-(diethylamino)ethyl methacrylate-based polymers

Cited by 16 publications

References 51 publications

Design and synthesis of cauliflower-shaped hydroxyl functionalized core-shell polymer

Design and synthesis of cauliflower-shaped hydroxyl functionalized core-shell polymer

The physical studies and interaction with anti-apoptotic proteins of 2-(bis(cyanomethyl)amino)-2-oxoethyl methacrylate molecule

Combinatorial screening of polymer nanoparticles for their ability to recognize epitopes of AAV‐neutralizing antibodies

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