Synthesis, crystal structure and biological activity of bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV)

Teoh, Siang-Guan; Ang, Show-Hing; Teo, Soon-Beng; Fun, Hoong‐Kun; Khew, Khing-Ling; Ong, Chi Wi

doi:10.1039/a605679b

Cited by 38 publications

(18 citation statements)

References 14 publications

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“…e N-and O-containing ligands and their complexes have become important due to their wide biological activities [2][3][4][5]. It is known that the existence of metal ions bonded to biological active material can enhance their activity [6]. Amino acids and their compounds with different metal ions play an important role in biology, pharmacy, and industry [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Gupta

Sihag

Varshney

et al. 2012

Journal of Chemistry

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Some new coordination compounds of palladium(II) have been synthesized by the reaction of palladium(II) acetate with azomethines in a 1 : 2 molar ratio using acetonitrile as a reaction medium. Azomethines used in these studies have been prepared by the condensation of 2-acetyl �uorene and 4-acetyl biphenyl with glycine, alanine, valine, and leucine in methanol. An attempt has been made to probe their bonding and structures on the basis of elemental analyses and IR, 1 H, and 13 C NMR spectral studies. Pd(II) compounds have been found to be more active than their uncomplexed ligands as both of them were screened for antibacterial, antifungal, and insecticidal activities.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Gupta

Sihag

Varshney

et al. 2012

Journal of Chemistry

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“…Taking into account that thiosemicarbazone molecules show cytotoxic activity [20] and that transition metal compounds may have antitumor properties [21], we have tested the ability of the Co(II) complex to inhibit tumor cell growth. In our experiment, IC 50 values (compound concentration that produces 50 % of cell death) in micro molar units were calculated for the free ligand and the complex against lung cancer A549 cell lines.…”

Section: In Vitro Cytotoxic Activitymentioning

confidence: 99%

Synthesis, Crystal Structure and Antitumor Study of a Cobalt(II) Complex of the 2-Acetylpyrazine Thiosemicarbazone

Zhou

Wang

et al. 2008

Zeitschrift Für Naturforschung B

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The title complex [Co(C 7 H 8 N 5 S) 2 ]·2H 2 O has been synthesized and characterized by IR and UV spectral studies. The structure of the compound has been determined by single-crystal X-ray diffraction. The complex consists of discrete monomeric molecules with octahedrally hexacoordinate cobalt(II) ions, where two acetylpyrazine thiosemicarbazones act as NNS tridentate ligands coordinated to the central cobalt atom via the pyrazine nitrogen, azomethine nitrogen and sulfur atoms. Hydrogen bonds link the different components to stabilize the crystal structure. The antitumor activity of the title complex was tested against A549 lung cancer cell line. The complex exhibited lower antitumor activity, as compared to the free ligand.

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“…Organotin(IV) complexes are extensively studied due to the applications in industrial as well as biocidal properties [11][12][13]. Numerous studies on organotin(IV) complexes have been carried out in order to study its biological properties against bacterial, fungal, and cancer cell lines [14][15][16]. In addition to this, organotin(IV) complexes are also extensively studied due to its coordination geometries as well as structural diversity [17,18].…”

Section: Introductionmentioning

confidence: 99%

Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

Singh

Sharma

2011

Res Chem Intermed

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Reaction of dibutyltin dichloride, dimethyltin dichloride, and tributyltin chloride with ligands derived from thiosemicarbazone and semicarbazone leads to the formation of a new series of organotin(IV) complexes of general formula R 2 SnCl 2 ÁL and R 3 SnClÁL (where L ligands derived from the condensation of thiosemicarbazide and semicarbazide with 4-hydroxy-3-methoxybenzaldehyde). The authenticity of these ligands and their metal complexes have been established on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, 1 H NMR, 13 C NMR, 119 Sn NMR, and UV spectral studies. These studies showed that the ligands coordinate to the metal atom in a bidentate. An octahedral structure is proposed for the organotin(IV) complexes. The ligands and its metal complexes are screened for their antimicrobial activities against some Gram-positive and Gram-negative bacteria, and fungus. The studies demonstrated that metalation can increase the antimicrobial activity rather than the free ligands.

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Synthesis, crystal structure and biological activity of bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV)

Cited by 38 publications

References 14 publications

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Synthesis, Crystal Structure and Antitumor Study of a Cobalt(II) Complex of the 2-Acetylpyrazine Thiosemicarbazone

Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

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