Synthesis, computational and biological study of pyrazole derivatives

Manju, N.; Kalluraya, Balakrishna; Asma, -; Kumar, Mohit

doi:10.1016/j.molstruc.2019.05.049

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…“One of the synthesized compound 3 was recrystallized by slow evaporation method and resolved by direct methods and refined by full‐matrix least‐squares method on F 2 using SHELXS and SHELXL program. [ 44,45 ] The geometrical calculations were carried out using the program PLATON . [ 46 ] The molecular structure and packing diagrams were generated with the help of MERCURY software.” [ 47 ] Crystallographic data for the compound 3 has been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 1857132, copies of this information may be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of chalcone precursor via Cu(I) catalyzed 1,3‐dipolar reaction of functionalized acetylene and pyrazole embedded dipole

Manju

Kalluraya

Asma

et al. 2020

Journal of Heterocyclic Chem

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A new class of functionalized pyrazole bearing 1,2,3-triazole has been synthesized via Cu(I) mediated 1,3-dipolar cycloaddition of pyrazole bearing azide with various aromatic/heteroaromatic bearing terminal dipolarophile (acetylene). Structures of the newly synthesized compounds were explicated by analytical and spectral analysis. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antioxidant activity. Among the synthesized compound, triazole bearing 2,5-thiazolidinone 5b (20 ± 0.70) and triazole bearing thiocarboamide 5e (19 ± 0.70) showed good antibacterial activity against Escherichia coli and Pseudomonas aeruginosa, respectively. The newly synthesized compounds further tested for their ability to bleach DPPH radical using DPPH scavenging assay. Among the synthesized compounds 1,2,3-triazole bearing 2,5-thiazolidinone 5b (58.81%) exhibited good DPPH scavenging activity compared to the rest of the compounds. From the X-ray and Hirshfield analysis, it was observed that compound 3, crystallizes in a triclinic crystal system with a P-1 space group. The major intercontacts present in these molecules are H…H (39.7%), C…H (23.9%), N…H (20.3%).

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Section: Resultsmentioning

confidence: 99%

Synthesis of chalcone precursor via Cu(I) catalyzed 1,3‐dipolar reaction of functionalized acetylene and pyrazole embedded dipole

Manju

Kalluraya

Asma

et al. 2020

Journal of Heterocyclic Chem

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“…The resultant solid is recrystallized using ethanol. And the reaction scheme is shown in Scheme 1 (Manju et al, 2019).…”

Section: Synthesismentioning

confidence: 99%

Antioxidant studies of 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1Hpyrazole-4-yl)-1-(furan-2-yl)prop-2-en-1-one

Somashekarachar¹,

Goswami²,

Ravindranath³

et al. 2021

ijrps

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Chalcones are flavonoid precursors, abundant in edible plants. The pyrazole moieties in chalcones show various pharmacological activities. Notably, Chalcone-based structures exhibit numerous pharmacological activities like antiinflammatory, antibacterial, antitumor, antioxidant functions because of having α, β-unsaturated ketone moiety. Such broad spectrum biological activities were also observed in several nitrogen containing heterocycles. Among the heterocyclic systems, pyrazole stand unique. All these observations led us to design and synthesize pyrazole fused hybrid thiophenechalcone molecule 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1H-pyrazole-4-yl)-1-(furan-2-yl)prop-2-en-1-one (3a). The synthesis was performed using base catalyzed reaction of pyrazole aldehyde and acetyl furan. Further characterization of the molecule was done by spectroscopy and antioxidant studies. Spectroscopic methods included Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and mass spectra (MS). The antioxidant potency of the compound was carried out based on the scavenging activity of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH). This compound showed moderate free radical scavenging activity of 45.12 %.

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“…As a result, numerous homogeneous and heterogeneous catalysts have been developed for oxidation reactions employing ecologically friendly oxidants such as H 2 O 2 with tert-butyl hydroperoxide (TBHP), which is secure, affordable, and less impacted by the environment. [1][2][3] Studies of cobalt compounds derived from various ligands have been developed because of their intriguing biological features, particularly those utilized in vitamin B 12 [4][5][6][7][8] Due to their remarkable electron-transfer characteristics, transition metal ions are well known for being catalytic. A change in the coordination environment around the metal ion due to its changing oxidation states is a significant component in determining its catalytic activities.…”

Section: Introductionmentioning

confidence: 99%

“…Studies of cobalt compounds derived from various ligands have been developed because of their intriguing biological features, particularly those utilized in vitamin B 12 [4–8] Due to their remarkable electron‐transfer characteristics, transition metal ions are well known for being catalytic. A change in the coordination environment around the metal ion due to its changing oxidation states is a significant component in determining its catalytic activities.…”

Section: Introductionmentioning

confidence: 99%

Solvent Free, Selective Oxidation of Styrene Catalyzed by Cobalt Acylpyrazolone Supported onto Neutral Alumina: Synthesis and Spectral Characterization

Vala,

Puranik,

Jadeja

et al. 2024

ChemistrySelect

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The present work describes the synthesis of the Cobalt acylpyrazolone complex supported over neutral alumina and its use as a heterogeneous catalyst for selective oxidation of styrene. The catalyst mentioned here was characterized by various physicochemical techniques such as FT‐IR, TGA, CV, SCXRD, PXRD and BET. This heterogeneous catalyst has successfully been used to oxidize styrene to benzaldehyde in a solvent‐free condition with good conversion (87 %) and high selectivity (90 %) using H2O2 and TBHP as oxidants. The effects of the reaction parameters (catalyst concentration, reaction duration, and temperature) have also been investigated. The existing complex was discovered to be recyclable and sustainable with no change in conversion or selectivity for benzaldehyde. FT‐IR spectra of the regenerated catalyst indicated that the catalyst was undegraded and stable after the reaction. The novel feature of the current work reported in this paper is the selective oxidation of styrene without the need for solvents under mild conditions. Single Crystal Analysis.

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Synthesis, computational and biological study of pyrazole derivatives

Cited by 10 publications

References 24 publications

Synthesis of chalcone precursor via Cu(I) catalyzed 1,3‐dipolar reaction of functionalized acetylene and pyrazole embedded dipole

Synthesis of chalcone precursor via Cu(I) catalyzed 1,3‐dipolar reaction of functionalized acetylene and pyrazole embedded dipole

Antioxidant studies of 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1Hpyrazole-4-yl)-1-(furan-2-yl)prop-2-en-1-one

Solvent Free, Selective Oxidation of Styrene Catalyzed by Cobalt Acylpyrazolone Supported onto Neutral Alumina: Synthesis and Spectral Characterization

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