Chalcones are flavonoid precursors, abundant in edible plants. The pyrazole moieties in chalcones show various pharmacological activities. Notably, Chalcone-based structures exhibit numerous pharmacological activities like antiinflammatory, antibacterial, antitumor, antioxidant functions because of having α, β-unsaturated ketone moiety. Such broad spectrum biological activities were also observed in several nitrogen containing heterocycles. Among the heterocyclic systems, pyrazole stand unique. All these observations led us to design and synthesize pyrazole fused hybrid thiophenechalcone molecule 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1H-pyrazole-4-yl)-1-(furan-2-yl)prop-2-en-1-one (3a). The synthesis was performed using base catalyzed reaction of pyrazole aldehyde and acetyl furan. Further characterization of the molecule was done by spectroscopy and antioxidant studies. Spectroscopic methods included Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and mass spectra (MS). The antioxidant potency of the compound was carried out based on the scavenging activity of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH). This compound showed moderate free radical scavenging activity of 45.12 %.
BACKGROUND Forensic odontology is a branch of dentistry which deals with appropriate handling and examination of dental evidences and with the proper evaluation and presentation of dental findings in the interest of justice. Identification of an individual is a prerequisite for certification of death and for personal, social and legal reasons. Palatal rugae are permanent and unique to each person, and can be used by clinicians and scientists to establish identity. It can be of special interest in edentulous cases and also in certain conditions, such as burned bodies or bodies that underwent severe decomposition. Thus the uniqueness, postmortem resistance, overall stability and additionally low utilization cost makes palatal rugae ideal forensic identification parameters. We wanted to compare the various palatal rugae patterns between dentate and edentulous subjects and also determine the comparison of the distribution of rugae number, length, shape, direction, unification between dentate and edentulous subjects. METHODS The study sample consisted of 60 subjects, 30 dentulous and 30 edentulous from JSS Dental College & Hospital, Mysuru. The study group was equally divided between the sex, and was observed for number, length, shape, direction and unification of all palatal rugae. RESULTS The total number of rugae was higher in the dentulous group than in the edentulous group. In edentulous group, shorter lengths, lesser complexity rugae were seen compared to dentulous subjects. The total number of rugae on the right side in dentulous casts were 4.20 ± 1.06, while the total number on right side in Edentulous casts were 4.16 ± 0.79. On the left side mean total number of rugae in dentulous casts was 4.46 ± 0.79 whereas the mean total number of rugae in edentulous casts was 3.76 ± 0.77. CONCLUSIONS Palatal rugae pattern changed greatly after aging and loss of teeth regardless of time of edentulism and wearing denture. KEY WORDS Dentulous, Edentulous, Palatal Rugae, Forensic Identification
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