This paper analyzes the universal concept that sonorants are marked geminates in the gemination process of Sylheti Bangla (henceforth SHB). Evidence from SHB suggests that when SHB speakers confront borrowed words with sonorant initial or obstruent initial heterosyllabic clusters, it is invariably the sonorant that gets assimilated. In addition, SHB data indicates that when faced with choices between two sonorants of the heterosyllabic clusters, speakers opt for the less sonorous one for gemination. Given this phenomenon, the proposal that sonorant gemination is absent in SHB could not be the ultimate one as it receives additional support from the fact that SHB also possesses many underlying sonorant geminations. Based on this investigation the hierarchy of the constraints *GG*RR>>*LL*NN is proposed for analyzing the gemination process in SHB. Finally, this paper illustrates some additional constraints in the SHB gemination process found to be necessary.
Chalcones are flavonoid precursors, abundant in edible plants. The pyrazole moieties in chalcones show various pharmacological activities. Notably, Chalcone-based structures exhibit numerous pharmacological activities like antiinflammatory, antibacterial, antitumor, antioxidant functions because of having α, β-unsaturated ketone moiety. Such broad spectrum biological activities were also observed in several nitrogen containing heterocycles. Among the heterocyclic systems, pyrazole stand unique. All these observations led us to design and synthesize pyrazole fused hybrid thiophenechalcone molecule 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1H-pyrazole-4-yl)-1-(furan-2-yl)prop-2-en-1-one (3a). The synthesis was performed using base catalyzed reaction of pyrazole aldehyde and acetyl furan. Further characterization of the molecule was done by spectroscopy and antioxidant studies. Spectroscopic methods included Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and mass spectra (MS). The antioxidant potency of the compound was carried out based on the scavenging activity of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH). This compound showed moderate free radical scavenging activity of 45.12 %.
Aims and Objectives: C-reactive protein is an acute-phase-reactant primarily produced by the liver in response to infection or trauma. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. This study aims to relate the serum-CRP level in chronic and aggressive periodontitis patients, before and after periodontal treatment, with healthy controls.
Materials and Method: A case-control clinical study was conducted with a total of 75 systemically healthy subjects, where 25 subjects were selected in each groups: Group I, Healthy control subjects; Group II, generalized chronic periodontitis patients, and Group III, generalized aggressive periodontitis patients. Serum-CRP levels were quantified by using turbidimetric immunoassay at baseline and 3month post-treatment. Kit used was “TURBILYTE-CRP” (Tulip Diagnostics, Goa, India). In the treatment phase, patients received single visit nonsurgical periodontal treatment, completed within 24hrs under LA for GCP & GAP group.
Results: Mean serum CRP levels were significantly higher in both GCP and GAP groups as compared to the control group at baseline. On comparing the clinical parameters at 3 months post-treatment for GCP & GAP group with control group values, the mean score of serum CRP levels for the GAP group was statistically significant (P<0.001) in comparison to the GCP group, which in turn was statistically significant as compared to control group.
Conclusion: The present study indicates a positive correlation between CRP and periodontal disease severity with particular concern in younger individuals, where it could be a possible underlying pathway in the association between periodontal disease and risk for cardiovascular disease in periodontitis patients.
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