Synthesis, characterization of α-terpineol-loaded PMMA nanoparticles as proposed of therapy for melanoma

Batista, Felipe Alves; Fontele, Sabryna Brena Cunha; Santos, Lubna Karine Beserra; Filgueiras, Lívia Alves; Nascimento, Steffane Quaresma; Sousa, João Marcelo de Castro e; Gonçalves, Juan Carlos Ramos; Mendes, Anderson Nogueira

doi:10.1016/j.mtcomm.2019.100762

Cited by 31 publications

(17 citation statements)

References 43 publications

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“…Zhang et al (2018) Antiproliferative activity in vitro on melanoma cell lines. Batista et al (2019) Antimutagenic activity in Ames' test and indirect antioxidant activity. Di Sotto et al (2013) Antidiarrheal activity in models of acute diarrhea in Swiss mice.…”

Section: Bicas Et Al (2011)mentioning

confidence: 99%

Production, Properties, and Applications of α-Terpineol

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Felipe

Bicas

2020

Food Bioprocess Technol

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α-Terpineol (CAS No. 98-55-5) is a tertiary monoterpenoid alcohol widely and commonly used in the flavors and fragrances industry for its sensory properties. It is present in different natural sources, but its production is mostly based on chemical hydration using α-pinene or turpentine. Moreover, many bioprocesses for the microbial production of α-terpineol via biotransformation of monoterpenes (limonene, αand β-pinenes) are also available in the literature. In addition to its traditional use, αterpineol has also been evaluated in other application fields (e.g., medical), since some biological properties other than aroma, such as antioxidant, anti-inflammatory, antiproliferative, antimicrobial, and analgesic effects, among others, have been attributed to this compound. Therefore, this review presents an original compilation of data regarding the production (extraction directly from nature; chemical synthesis; via biotechnological process), the chemical and biological properties, and the current market and novel applications of α-terpineol to guide further research in this area. Considering the information presented, we believe that αterpineol applications may transcend the flavors and fragrances industry in the future.

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Section: Bicas Et Al (2011)mentioning

confidence: 99%

Production, Properties, and Applications of α-Terpineol

Sales

Felipe

Bicas

2020

Food Bioprocess Technol

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“…Various types of polymer NPs can be synthesized depending on the properties of the polymer and their applications, namely nanospheres and nanocapsules, polymer micelles, polymers, dendrimer-based micelles, and polymer drug conjugates [ 40 ]. Very recently, Alves Batista and collaborators proposed the use of NPs, based on poly(methyl methacrylate) (PMMA) [ 52 ], with the ability to incorporate α-terpineol, a monoterpenoid known in the literature for exerting beneficial effects against leukemic cell lines [ 53 ]. The results suggest that α-terpineol increases its antitumor efficacy when incorporated into the PMMA/α-terpineol NPs and tested in melanoma-derived tumor cell lines.…”

Section: Nanoparticles Useful For Melanoma Treatmentmentioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Melanoma

et al. 2021

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Melanoma is one of the most aggressive forms of skin cancer, with few possibilities for therapeutic approaches, due to its multi-drug resistance and, consequently, low survival rate for patients. Conventional therapies for treatment melanoma include radiotherapy, chemotherapy, targeted therapy, and immunotherapy, which have various side effects. For this reason, in recent years, pharmaceutical and biomedical research has focused on new sito-specific alternative therapeutic strategies. In this regard, nanotechnology offers numerous benefits which could improve the life expectancy of melanoma patients with very low adverse effects. This review aims to examine the latest advances in nanotechnology as an innovative strategy for treating melanoma. In particular, the use of different types of nanoparticles, such as vesicles, polymers, metal-based, carbon nanotubes, dendrimers, solid lipid, microneedles, and their combination with immunotherapies and vaccines will be discussed.

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“…One of the main advantages of PMMA is that it contains less potentially harmful subunits from the synthesis, like bisphenol-A, commonly found in other types of polymers such as polycarbonates, polysulfones, and epoxy resins [ 5 ]. It is a superior polymeric material for analytical separation, sensing [ 6 ], biomedical and medical applications due to biocompatibility [ 7 , 8 ], and is used for electrolysis [ 9 ], polymer conductivity, viscosity measurements [ 10 , 11 ], solar nano/micro concentrator lens for solar cells [ 12 , 13 , 14 ]. In practice, the PMMA surface properties can be tailored by surface modification through graft copolymerization [ 15 ] or by the incorporation of a surfactant into the polymer matrix [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Is Poly(methyl methacrylate) (PMMA) a Suitable Substrate for ALD?: A Review

et al. 2021

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Poly (methyl methacrylate) (PMMA) is a thermoplastic synthetic polymer, which displays superior characteristics such as transparency, good tensile strength, and processability. Its performance can be improved by surface engineering via the use of functionalized thin film coatings, resulting in its versatility across a host of applications including, energy harvesting, dielectric layers and water purification. Modification of the PMMA surface can be achieved by atomic layer deposition (ALD), a vapor-phase, chemical deposition technique, which permits atomic-level control. However, PMMA presents a challenge for ALD due to its lack of active surface sites, necessary for gas precursor reaction, nucleation, and subsequent growth. The purpose of this review is to discuss the research related to the employment of PMMA as either a substrate, support, or masking layer over a range of ALD thin film growth techniques, namely, thermal, plasma-enhanced, and area-selective atomic layer deposition. It also highlights applications in the selected fields of flexible electronics, biomaterials, sensing, and photocatalysis, and underscores relevant characterization techniques. Further, it concludes with a prospective view of the role of ALD in PMMA processing.

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Synthesis, characterization of α-terpineol-loaded PMMA nanoparticles as proposed of therapy for melanoma

Cited by 31 publications

References 43 publications

Production, Properties, and Applications of α-Terpineol

Production, Properties, and Applications of α-Terpineol

Recent Advances in Nanotechnology for the Treatment of Melanoma

Is Poly(methyl methacrylate) (PMMA) a Suitable Substrate for ALD?: A Review

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