Synthesis, characterization, molecular docking and biological studies of self assembled transition metal dithiocarbamates of substituted pyrrole-2-carboxaldehyde

Nami, Shahab A.A.; Ullah, Irfan; Alam, Mahboob; Lee, Dong‐Ung; Sarikavakli, Nursabah

doi:10.1016/j.jphotobiol.2016.05.010

Cited by 22 publications

(12 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diseases such as Parkinson's disease, diabetes, Alzheimer's disease, asthma and cancer have a high possibility of occurring because of oxidative damage . The antioxidant activities of dithiocarbamate salts and their metal complexes have been reported . The ability of dithiocarbamates and metal complexes to scavenge free radicals may probably be due to the presence of the sulfur atoms on the dithiocarbamate ligand, which have the capability of donating electrons, and to the presence of transition metal ions in the complexes, which can stabilize free radicals .…”

Section: Resultsmentioning

confidence: 99%

Co(III) N,N′‐diarylformamidine dithiocarbamate complexes: Synthesis, characterization, crystal structures and biological studies

Oladipo

Omondi

Mocktar

2020

Applied Organom Chemis

View full text Add to dashboard Cite

Three symmetric N,N‐diarylformamidine dithiocarbamates, N,N′‐bis(2,6‐dimethylphenyl)formamidine dithiocarbamate (DTL1), N,N′‐bis(2,6‐disopropylphenyl)formamidine dithiocarbamate (DTL2) and N,N′‐dimesitylformamidine dithiocarbamate (DTL3), and three unsymmetric ones, N′‐(2,6‐dichlorophenyl‐N‐(2,6‐dimethylphenyl)formamidine dithiocarbamate (DTL4), N′‐(2,6‐dichlorophenyl)‐N‐(2,6‐diisopropylphenyl)formamidine dithiocarbamate (DTL5) and N′‐(2,6‐dichlorophenyl)‐N‐mesitylformamidine dithiocarbamate (DLT6), were reacted with chloridocobalt(III) in water to give Co‐(DTL1)3 (1), Co‐(DTL2)3 (2), Co‐(DTL3)3 (3), Co‐(DTL4)3 (4), Co‐(DTL5)3 (5) and Co‐(DTL6)3 (6). All the dithiocarbamates and complexes were characterized using 1H NMR, 13C NMR, Fourier transform infrared, UV–visible and mass spectra and the purity confirmed by elemental analysis. In addition, crystal structures of complexes 1, 2, 4 and 5 were determined, confirming the formation of mononuclear species in which the Co(III) centers coordinated to six sulfur atoms from three dithiocarbamate ligands resulting in distorted octahedral geometries. All complexes showed moderate to good antibacterial activities against Gram‐negative bacteria Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa even at low concentrations. None of the six were active against Gram‐positive bacterium methicillin‐resistant Staphylococcus aureus and only active against S. aureus at high concentrations. Complexes 5 and 6 were found to be more active than ciprofloxacin against S. typhimurium, E. coli, P. aeruginosa and K. pneumoniae and complexes with chloro‐substituted ligands generally had enhanced activities. Antioxidant activities of the dithiocarbamate salts and their Co(III) complexes were also investigated using DPPH assay and the complexes were found to be more efficient. Complex 2 with an IC50 value of 2.84 × 10−4 mM displayed the highest activity of all compounds tested, even outdoing ascorbic acid. The radical scavenging ability of the complexes followed the order 2 > 1 > ascorbic acid >3 > 4 > 6 > 5.

show abstract

Section: Resultsmentioning

confidence: 99%

Co(III) N,N′‐diarylformamidine dithiocarbamate complexes: Synthesis, characterization, crystal structures and biological studies

Oladipo

Omondi

Mocktar

2020

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…C 56 and L 56 were also investigated for their antimicrobial activity against B. subtilis S. pyogenes S. aureus P. aeruginosa K. pneumonia and E. coli . Here again C 56 revealed better inhibition zone diameters (17.5‐28.1 mm) than L 56 (14.1‐21.3 mm) . Definitely, the antioxidant activity of Mn complexes must be better than compared to respective ligands due to versatile oxidation states of Mn and its biocompatibility.…”

Section: Mn–complexes With Tetradentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

View full text Add to dashboard Cite

The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.

show abstract

“…(1) shows a distribution of four canonical forms of the dithiocarbamate ligands, all having an IR band in the regions 1480–1550 cm −1 corresponding to C-N bond and UV-Vis band in the regions 450 nm assignating to C-S 2 − bond, which appear and can be changed when they form a metal-containing complex [15]. These compounds can be easily synthetized from primary or secondary amines, and should have good solubility in water or organic solvents depending upon the nature of the cation [16].…”

Section: Chemical Aspectsmentioning

confidence: 99%

“…These complexes are sparingly soluble in water but more soluble in non-polar organic solvents such as chloroform, carbon tetrachloride and other. The ratio of 1: 2 (metal: dithiocarbamate) is mostly used, and the desired metal complex precipitates upon stirring the mixture for a few hours at room temperature, which can be purified by recrystallization [16, 17, 26, 27].…”

Section: Chemical Aspectsmentioning

confidence: 99%

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Viola-Rhenals

Patel

Jaimes-Santamaria

et al. 2018

CMC

View full text Add to dashboard Cite

show abstract

Synthesis, characterization, molecular docking and biological studies of self assembled transition metal dithiocarbamates of substituted pyrrole-2-carboxaldehyde

Cited by 22 publications

References 44 publications

Co(III) N,N′‐diarylformamidine dithiocarbamate complexes: Synthesis, characterization, crystal structures and biological studies

Co(III) N,N′‐diarylformamidine dithiocarbamate complexes: Synthesis, characterization, crystal structures and biological studies

Coordination Complexes of Manganese and Their Biomedical Applications

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Contact Info

Product

Resources

About