Synthesis, characterization, electrochemical behavior, and antimicrobial activities of aromatic/heteroaromatic sulfonylhydrazone derivatives

Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities

“…The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) are very important for quantum chemistry [37,38]. …”

Synthesis, characterization and electrochemical properties of some biologically important indole-based-sulfonamide derivatives

“…Thio-indole based analogs act as antifungal [6], antimicrobial [7], antibacterial, analgesic [8,9], anticonvulsant [10], antioxidant [11], antidepressant [12], antihypertensive [13], and antiviral agents [14]. Indole sulfonamide undergoes substitution, mainly at the C3 position, possess hydrophilic features like sulfonyl group, and is regarded as an appropriate pharmacophore equivalent for replacing active sites in drug design [15][16][17]. Consequently, the redox properties of the indole sulfonamide may be very useful for their efficient uses.…”

“…The electrochemical techniques have been effectively applied to study the redox properties of several biologically important compounds [20,21]. As reported previously, the redox behavior of indole derivatives was investigated using various electrodes: pyrolytic carbon [22], glassy carbon [17,23], platinum [24], lead dioxide [25] boron-doped diamond [26,27], and other electrodes [28][29][30]. Among the studied indole compounds with a substituent at C3, the results of electrochemical oxidation of indole-3-acetic acid, indole-3-propionic acid, indole-3-butyric acid, indol-3-acetamide, tryptamine, gramine and tryptophan were reported for the measurements done with the usage of a glassy carbon electrode as the working electrode [23,31].…”

Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives

“…That is, Segretti and collaborators started from two compounds with notorious biological activity to plan another compound of a new class-the sulfonyl hydrazones [16]. The sulfonyl hydrazones have similar chemical and biological properties as sulfonamides [8], and are of therapeutic interest because of their activities such as, antimicrobial [17], anticancer [18], anti-trypanosoma cruzi [19], inhibition of the enzyme acetylcholinesterase [20], among others.…”