Synthesis, characterization and electrochemical properties of some biologically important indole-based-sulfonamide derivatives

Abstract

A new series of indole-based-sulfonamide derivatives (A1-A8) was synthesized by treating 5-fluoro-1H-indole-3-carbohydrazide with different aryl-sulfonyl chloride in the presence of pyridine. All synthesized derivatives (A1-A8) were characterized by different analytical methods. The electrochemical behavior of these compounds (A1-A8) was investigated in detail using cyclic voltammetry (CV) and square wave voltammetry (SWV) at the pencil graphite electrode (PGE). In the present study, the redox behavior of all derivatives varies due to the nature of substitutions in the indole sulfonamide moiety. Various fundamental electrochemical parameters, including the standard heterogeneous rate constants (k s), and the electroactive surface coverage (Г) were calculated from the obtained CVs. The obtained results shed light on the understanding of structure-activity relationships of this class of compounds.

Microwave assisted synthesis of 2-amino-4-chloro-pyrimidine derivatives: Anticancer and computational study on potential inhibitory action against COVID-19

“…Our research group has been working on multifunctional amino derivatives synthesis ( Nawaz et al, 2020 , Rahim etal., 2020, Taha etal., 2020, Gollapalli at al., 2018, Taha et al, 2018 , Ibrahim et al, 2020 ) with antidiabetic and cytotoxic activity ( Qureshi et al, 2020 , Nawaz et al, 2022 ), and for this research we synthesized pyrimidine derivatives. Pyrmidine, a multi therapeutical nitrogen carrying heterocyclic ring, proven against carbohydrate digesting enzymes, bacteria and even cancer cell line ( Taha et al, 2017 , Slyusarenko et al, 1989 , Nawaz et al, 2016 , Soylem et al, 2017 , Altaf et al, 2015 , Krause et al, 2017 , Salar et al, 2017 ) and also many other therapeutic benefits, was selected as parent molecule, to be treated with a variety of functional moieties and the resulting compounds were characterized as per protocol.…”