Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities

Özdemir, Uğur; İlbiz, Firdevs; Gündüzalp, Ayla Balaban; Özbek, Neslihan; Genç, Zuhal Karagöz; Hamurcu, Fatma; Tekin, Suat

doi:10.1016/j.molstruc.2015.07.054

Cited by 29 publications

(20 citation statements)

References 37 publications

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“…The magnetic susceptibility for Ni(II) -complex shows a paramagnetic behavior and the µeff value equal 2.69 B.M. indicating the octahedral geometry because of the presence of two unpaired electrons (t2g 6 eg 2 ) high-spin and sp 3 d 2 hybrization [39]. Table 2.…”

Section: Magnetic Susceptibility and Electronic Spectra Measurementsmentioning

confidence: 96%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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New heterocyclic azo-schiff base dye (L2) have been synthesized from a reaction of 4-(dimethylamino)benzaldehyde with (E)-5-((1H-benzo[d]imidazol-2-yl) diazenyl) -2amine-4,6-dimethylpyridin (L1) . A new class of Ni(II), Pd(II), and Pt(IV) complexes of azo-schiff base of the type [Ni(L2)2Cl2], [Pd(L2) Cl2] , and [Pt-2amine-4,6-dimethylpyridin. Both ligand and its metal complexes were characterized by the spectroscopic and analytical methods such as mass spectral, 1 H-NMR, FT-IR, UV-Visb.,X-ray, TGA and SEM, elemental analysis, molar conductance measurements and magnetic susceptibility., spectral studies suggest the mole ratio [M:L] was [1:2] for Ni(II) and Pt(IV) metal ions, but [1:1] for Pd(II) metal ion. The structures of theses complexes were elucidated on the basis of different techniques suggest the structures of the prepared metal complexes octahedral geometry for the Ni(II) and Pt(IV) complexes and square planar geometry for the Pd(II) complex. The antibacterial activity of the ligand and prepared metal complexes was also studied against gram positive Staphylococcus aureus and gram negative bacteria Escherichia coli, the antifungal activity of the azo-schiff base and metal complexes against the fungi Alternaria. It is found that some of the complexes are quite effective against fungi Alternaria. In this study the cytotoxicity of Pd(II)-complex on human (PC3) cancer and normal cells were studied using MTT assay. Pd(II)-complex showed selective cytotoxicity against cancer cell line with IC50 = 450 μg/ml, while it was very safe on normal cells line with IC50 = 14554885 μg /ml, respectively for human cells .The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of medicine and Pharmacy against prostate cancer.

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Section: Magnetic Susceptibility and Electronic Spectra Measurementsmentioning

confidence: 96%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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“…Thus, biological activity of synthesized compounds increases with decrease in the energy gap. The order of ranking should be [ 38 , 40 , 41 ]: Compound 5f > Compound 5e > Compound 5h > Compound 5d > Compound 5a > Compound 5c ≈ Compound 5g > Compound 5b …”

Section: Resultsmentioning

confidence: 99%

“…All computational calculations of compounds were carried through Gaussian 09W program supported by the Gauss View 6.0.16 interface [ 65 ]. The molecules are optimized and its parameters calculated operating hybrid type B3LYP utilizing 321-G basis set with DFT exchange, which provide HOMO-LUMO geometries, net charge, energy gap, dipole moment and other computational descriptors [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

et al. 2021

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Objective: In this study, small molecules possessing tetrahydropyrimidine derivatives have been synthesized having halogenated benzyl derivatives and carboxylate linkage. As previously reported, FDA approved halogenated pyrimidine derivatives prompted us to synthesize novel compounds in order to evaluate their biological potential. Methodology: Eight pyrimidine derivatives have been synthesized from ethyl acetoacetate, secondary amine, aromatic benzaldehyde by adding catalytic amount of CuCl2·2H2O via solvent less Grindstone multicomponent reagent method. Molecular structure reactivity and virtual screening were performed to check their biological efficacy as an anti-oxidant, anti-cancer and anti-diabetic agent. These studies were supported by in vitro analysis and QSAR studies. Results: After combined experimental and virtual screening 5c, 5g and 5e could serve as lead compounds, having low IC50 and high binding affinity.

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“…[1][2][3][4][5] These compounds have gained importance in bioinorganic and metal based drug chemistry because of their lower cost, lower toxicity and most activity against bacterial diseases. 6,7 Moreover, they are used in agriculture field as well as insecticides and herbicides. They are less toxic as compared to other drugs and are scalable.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Photochemical Reactions of some Metal Carbonyls with N´-(2-Hydroxy-6- Methylbenzylidene)Methanesulfonohydrazide and 5-Methyl- 2-Hydroxyacetophenonemethanesulfonylhydrazone

Sert

2021

ACSi

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Eight new complexes, [M(CO) 5 (5msalmsh)] [M=Cr;(1a), Mo;(2a); W(3a)], [Re(CO) 4 Br(5msalmsh)] (4a), [M(CO) 5 (5mafmsh)] [M=Cr;(1b), Mo;(2b); W(3b)], [Re(CO) 4 Br(5mafmsh)] (4b), have been synthesized by the photochemical reaction of the metal carbonyls [M(CO) 6 ] (M=Cr, Mo, W) and [Re(CO) 5 Br] with N´-(2-Hydroxy-6-Methylbenzylidene) Methanesulfonohydrazide ( 5msalmsh) and 5-methyl-2-hydroxyacetophenonemethanesulfonylhydrazone (5mafmsh). The complexes have been characterized by elemental analysis, LC-MS, FT-IR, 1 H NMR spectroscopy. Spectroscopic studies show that 5msalmsh and 5mafmsh behave monodentate ligand and coordinate via an imine N donor atom to the central metal atom in (1a)-( 4a) and ( 1b)-(4b).

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Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities

Cited by 29 publications

References 37 publications

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Investigation of Photochemical Reactions of some Metal Carbonyls with N´-(2-Hydroxy-6- Methylbenzylidene)Methanesulfonohydrazide and 5-Methyl- 2-Hydroxyacetophenonemethanesulfonylhydrazone

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