Synthesis, characterization, antiproliferative and molecular docking study of new half sandwich Ir(III), Rh(III) and Ru(II) complexes

Thangavel, Saravanan; Paulpandi, Manickam; Friedrich, Holger B.; Murugan, Kadarkarai; Kalva, Sukesh; Skelton, Adam A.

doi:10.1016/j.jinorgbio.2016.02.006

Cited by 40 publications

(17 citation statements)

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“…Prostaglandins are involved in normal physiological functions and they are involved with tumour cell growth while overexpressing . Inhibition of prostaglandin synthesis is the primary target of several nonsteroidal anti‐inflammatory drugs, and cyclooxygenase (COX) is an essential enzyme in prostaglandin formation.…”

Section: Resultsmentioning

confidence: 99%

“…Inhibition of prostaglandin synthesis is the primary target of several nonsteroidal anti‐inflammatory drugs, and cyclooxygenase (COX) is an essential enzyme in prostaglandin formation. COX‐2 is an inducible form of the enzyme that is usually not expressed in normal tissue . COX‐2 receptor overexpression increases in the production of mutagens, which further causes DNA damage as tumour initiators (prostaglandin formation).…”

Section: Resultsmentioning

confidence: 99%

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Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Mahmoud

Elsawy

Radwan

2018

Applied Organom Chemis

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A new Schiff base was prepared as the condensation product of the reaction of 2‐quinoline carboxaldehyde and ambroxol drug. The Schiff base ligand thus obtained (HL; trans‐4‐[(2‐(2‐quinolinoimino)‐3,5‐dibromobenzyl)amino]cyclohexanol) was further employed as a tridentate ligand for the synthesis of new complexes through reaction with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions. The synthesized HL and its metal complexes were characterized using various physicochemical techniques including elemental analysis, Fourier transform infrared and UV–visible spectroscopies, conductimetric and magnetic susceptibility measurements, mass spectrometry and thermal analyses. 1H NMR data indicated that complex formation was through the amino group rather than the aliphatic hydroxyl group. Thermal analysis gave an idea about the decomposition pattern of HL and its complexes. Also, it revealed the number of water molecules in the inner and outer spheres of the complexes. An octahedral geometry for all the complexes has been suggested. HL and its complexes were screened for their antimicrobial activity against various species of bacteria and fungi using the disc diffusion method. The Cr(III) complex had the highest antimicrobial activity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Mahmoud

Elsawy

Radwan

2018

Applied Organom Chemis

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“…The MCF‐7 cancer cells were treated with doxorubicinin in the same concentration range and used as a control, which showed a high proliferation activity depending on the dose. The Mn(II) complex showed the lowest IC 50 value among all the complexes of 9.2 μg/mL, which was more effective against the breast cancer cell line than free ligand HL itself (Table ) . Another comparison of the cytotoxic activities with a novel Schiff base ligand H 2 l (made from the condensation of 2,6‐diaminopyridine and o ‐benzoylbenzoic acid in 1:2 ratio) showed that H 2 l had no antibreast cancer activity but HL had with the IC 50 of 58 μg/mL, which means the valuable cytotoxic activity of ferrocene‐based Schiff base ligand HL compared to other Schiff base ligands…”

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of nanobidentate ferrocene‐based Schiff base ligand and its coordination complexes: Antimicrobial, anticancer, density functional theory, and molecular operating environment studies

Mahmoud

2019

J Chinese Chemical Soc

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A novel bidentate Schiff base ligand (HL, Nanobidentate Ferrocene based Schiff base ligand L (has one replaceable proton H)) was prepared via the condensation of 2‐amino phenol with 2‐acetyl ferrocene. The ligand was characterized using elemental analysis, mass spectrometry, infrared (IR) spectroscopy, 1proton nuclear magnetic resonance (H‐NMR) spectroscopy, scanning electron microscopy (SEM), and thermal analysis. The corresponding 1:1 metal complexes with some transition‐metal ions were additionally characterized by their elemental analysis, molar conductance, SEM, and thermogravimetric ana1ysis (TGA). The complexes had the general formula [M(L)(Cl)(H2O)3]xCl·nH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)), (x = 0 for Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II), x = 1 for Cr(III) and Fe(III)), (n = 1 for Cr(III), n = 3 for Mn(II) and Co(II), n = 4 for Fe(III), Ni(II), Cu(II), Zn(II), and Cd(II)). Density functional theory calculations on the HL ligand were also carried out in order to clarify molecular structures by the B31YP exchange‐correlation function. The results were subjected to molecular orbital diagram, highest occupied mo1ecu1ar orbital–lowest occupied molecular orbital, and molecular electrostatic potential calculations. The parent Schiff base and its eight metal complexes were assayed against four bacterial species (two Gram‐negative and two‐Gram positive) and four different antifungal species. The HL ligand was docked using molecular operating environment 2008 with crystal structures of oxidoreductase (1CX2), protein phosphatase of the fungus Candida albicans (5JPE), Gram(−) bacteria Escherichia coli (3T88), Gram(+) bacteria Staphylococcus aureus (3Q8U), and an androgen‐independent receptor of prostate cancer (1GS4). In order to assess cytotoxic nature of the prepared HL ligand and its complexes, the compounds were screened against the Michigan cancer foundation (MCF)‐7 breast cancer cell line, and the IC50 values of compounds were calculated.

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“…Piano-stool complexes have applications in catalysis, supramolecular assemblies, molecular devices and have shown antiviral, antibiotic and anticancer activities [1,2]. Three-legged piano stool complexes of Ru possess a pseudo octahedral geometry at the ruthenium atom arene ligand occupying three coordinating sites (the seat) with three other ligands.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of chlorido-(N-(2,5-dichlorophenyl)-1-(pyridin-2-yl)methanimine-κ² N,N′)(η ⁶-1-isopropyl-4-methyl benzene) ruthenium (II) tetrafluoroborate, C₂₂H₂₂Cl₃N₂BF₄Ru

Gichumbi

Omondi

Friedrich

2017

Zeitschrift Für Kristallographie - New Crystal Structures

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C 22 H 22 Cl 3 N 2 BF4Ru, monoclinic, P21/n (no. 14), a = 15.067 (5) CCDC no.: 1529917The crystal structure is shown in the figure. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Synthesis and crystallizationTo a suspension of [(η 6 -p-cymene)Ru(µ -Cl)Cl] 2 (0.2 mmol) in methanol (20 mL) was added 2,5-dichlorophenyl(pyridin-2-yl) methylene amine (0.42 mmol). The mixture was stirred at room temperature for 3 h followed by the reduction of the solvent volume in vacuo to about (10 mL) before adding NaBF4 (0.42 mmol). The mixture was then cooled in an ice bath while stirring for 2 h leading to a precipitate which was collected by filtration.

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Synthesis, characterization, antiproliferative and molecular docking study of new half sandwich Ir(III), Rh(III) and Ru(II) complexes

Cited by 40 publications

References 54 publications

Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Physicochemical characterization of nanobidentate ferrocene‐based Schiff base ligand and its coordination complexes: Antimicrobial, anticancer, density functional theory, and molecular operating environment studies

Crystal structure of chlorido-(N-(2,5-dichlorophenyl)-1-(pyridin-2-yl)methanimine-κ² N,N′)(η ⁶-1-isopropyl-4-methyl benzene) ruthenium (II) tetrafluoroborate, C₂₂H₂₂Cl₃N₂BF₄Ru

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Synthesis, characterization, antiproliferative and molecular docking study of new half sandwich Ir(III), Rh(III) and Ru(II) complexes

Cited by 40 publications

References 54 publications

Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Metal complexes of novel Schiff base derived from the condensation of 2‐quinoline carboxaldehyde and ambroxol drug with some transition metal ions

Physicochemical characterization of nanobidentate ferrocene‐based Schiff base ligand and its coordination complexes: Antimicrobial, anticancer, density functional theory, and molecular operating environment studies

Crystal structure of chlorido-(N-(2,5-dichlorophenyl)-1-(pyridin-2-yl)methanimine-κ2 N,N′)(η 6-1-isopropyl-4-methyl benzene) ruthenium (II) tetrafluoroborate, C22H22Cl3N2BF4Ru

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Crystal structure of chlorido-(N-(2,5-dichlorophenyl)-1-(pyridin-2-yl)methanimine-κ² N,N′)(η ⁶-1-isopropyl-4-methyl benzene) ruthenium (II) tetrafluoroborate, C₂₂H₂₂Cl₃N₂BF₄Ru