Synthesis, Characterization, Antibacterial and Urease Inhibition Studies of Some Novel Symmetrical N3,N3'-bis-(disubstituted)isophthalyl-bis-(thioureas)

Abstract

Urease inhibitors are considered new targets for antiulcer drugs 1 . The activity of bacterial ureases has been proved to be important virulence factor in the development of many dangerous and harmful clinical conditions for human and animal health as well as agriculture 2 . Bacterial ureases have been reported to play a role in the formation of infectious stones 3 and development of peptic ulcers and stomach cancer 4 . Ureases also actively contribute to the development of pyelonephritis, urolithiasis, hepatic coma, hepatic encephalopathy andurinary catheter encrustation 5 . In the near past, many compounds have been proposed as urease inhibitors to reduce environmental problems and enhance the uptake of urea nitrogen by plants [6][7][8][9] . By urease inhibition, the treatment of infections caused by urease producing bacteria may also be possible.Thiourea derivatives possess wide spread applications in the field of medicine, agriculture and analytical chemistry. These compounds exhibit a comprehensive range of biological activities such as antiviral 10,11 , antibacterial 12 , fungicidal 13,14 ,

Electrochemical Studies Of Novel 3,4-Dichloro-N-((5-ChloroPyridin-2-yl)Carbamothioyl)Benzamide Based On Its Complexes With Copper(II), Cobalt(II), Nickel(II) and Zinc(II) ions

“…The magnetic moment of the As expected. These results in agreement with previous literature data [37][38][39]. Table 3 presents the observed magnetic moments of the prepared complexes.…”

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

“…Jamil and co-workers reported the results of a screen for symmetrical isophthalyl- bis -(thioureas) ( Scheme 10 ) [61] . The presence of an electron-withdrawing substituent at each terminal nitrogen was identified as a crucial factor determining the inhibitory activity of the four most active compounds ( 27 – 30 ).…”

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

“…Four symmetric isophthaloyl bis‐thiourea derivative 107 having amino acid linkers were prepared from reaction of isophthaloyl dichloride 104 with ammonium thiocyanate followed by addition of the appropriate amino acid 106 in dry acetone (Scheme ) . Further, the N , N ‐disubstituted isophthaloyl‐bis‐thiourea 109 was prepared in high yields by reaction of isophthaloyl isothiocyanate 105 with the secondary amine 108 in dry acetone (Scheme ) .…”