Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Abstract

Bis‐thiourea derivatives have distinguished synthetic potentialities. They are interesting substrates for construction of various classes of heterocycles, such as thiazoles, thiadiazoles, imidazoles, bis‐thiazoles, bis‐thiadiazoles, and fused heterocyclic systems. The current review is concerned on disclosing the synthetic and research applications of bis‐thioureas that were reported in the literature during the last decade.

Novel Bis-Thiazole Derivatives: Synthesis and Potential Cytotoxic Activity Through Apoptosis With Molecular Docking Approaches

“…Our research interest is focused on the synthesis and biological evaluation of thiazole-based heterocycles (Abdel-Gawad et al, 2010;Dawood and EI-Deftar, 2010;Hegazi et al, 2010;Dawood et al, 2011;Dawood et al, 2013;Dawood and Abu-Deif, 2014;Dawood, 2019;Mahmoud et al, 2020). Therefore, keeping the above facts in mind and inspired by the reported extraordinary bioactivity behaviors of thiazole and 4thiazolidinone derivatives, the objective of the current study is to design and synthesize new bis-thiazole structures for examining their potency against several of human cancer cell lines as well as investigating their effects as an inducer of apoptosis on the tested cancer cells.…”

A novel benzoylthiourea derivative with a triazinethione moiety: Synthesis and coordination with the organometallic fac-[Re(CO)3]+ core

“…The sulfidation of triazine using phosphorus oxychloride and hydrogen sulfide has been also reported as a synthetic route to triazinethione derivatives [31]. The less common method reported for the synthetic route to triazinethione derivatives involves the reaction of thiourea derivatives with sodium methoxide and the ring closure of dithiobiuret with a base [32,33]. Another reported method consists of the reactions of isothiocyanates with dithiobiuret but this reaction requires high pressure and triethylamine to get a good yields (>76%) for triazinethione derivatives.…”

Design and synthesis of new bis(1,2,4-triazolo[3,4-b][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition

“…During our research program aiming at synthesis of triazolebased fused heterocycles, bis(carboxamides) and bis(heterocycles) as twin drugs of signicant biological applications, [45][46][47][48][49][50][51][52][53][54][55] the reported anticancer activities of compounds employing either triazolothiadiazine or carboxamide pharmacophores inspired us to construct a series of modied novel bistriazolothiadiazine hybrids (Fig. 3) having variable bis(carboxamide) spacers, starting from bis(2-chloroacetamide) derivatives, to investigate their potency as anticancer agents against a panel of cancer cell lines and to investigate the effective molecular target and the apoptotic cell death.…”