Synthesis, Characterization and Pharmacological Activities of 3,6‐Disubstituted‐1,2,4‐triazolo [3,4‐b]‐1,3,4‐thiadiazoles and their Dihydro Analogues

Abstract

4-Amino-5-aryl/heteroaryl substituted-3-mercapto-1,2,4-triazoles 3(a-d) were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. Compounds 3(a-d) were made to react with various aromatic/hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles respectively. Elemental analysis, IR,1H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities.

Synthesis, Characterization and Antimicrobial Activities of 1,2,4-Triazole /Isatin Schiff bases and their Mn(II), Co(II) complexes

“…These compounds were also synthesized by conventional method 26 . In microwave method, the reaction time reduced from 6 hrs.to 3-5 minutes (3a-h) and from4 hrs.to 4-7 minutes (4a-p).…”

“…The reactions, which are not possible under normal conditions,can be overcome by high-energy microwave irradiation.Thereforwe have made efforts to develop and optimize anew environmentally benign method using microwave irradiation in our laboratory and finally 3-substituted-4-amino-5-mercapto-1,2,4-triazole 25 and isatin derivatives have been synthesized. These compounds were also prepared by conventional methods 26 to compare their results with new microwave irradiation method. The newly synthesized compounds were characterized by spectral as well as elemental analysis and screened for their biological activities.…”

Facile Synthesis and Antimicrobial Activities of 5H-[1,2,4]triazol[1,3,4]thiadiazine Derivatives

“…The intermediate 4-amino-5-substituted-1,2,4-triazole-3-thiols (3) were prepared in three steps by new environmentally benign solvent free methods (Scheme 1) using microwave irradiation as well as by conventional methods 26 . …”

Synthesis, Characterization and Biological Evaluation of a Novel Series of 1,2,4‐Triazolo‐[3,4‐b]‐1,3,4‐thiadiazines Containing an Amide Linkage

“…Synthesis of nitrogen containing heterocyclic systems has been attracting increasing interest over the past decades because of their utility in various applications. Over the years, a special attention has been given to N ‐bridged heterocyclic systems derived from 1,2,4‐triazoles owing to their promising biological activities such as antihypertensive, antimicrobial, anticonvulsant, antidepressant, analgesic, antitumor , and so forth. Many pyrazole derivatives make up the core structure of numerous biologically active molecules.…”