Synthesis, Characterization and Antimicrobial Activities of 1,2,4-Triazole /Isatin Schiff bases and their Mn(II), Co(II) complexes

Bajroliya, Sunita; Kalwania, G. S.; Choudhary, Savita; Chomal, S.

doi:10.13005/ojc/300419

Cited by 5 publications

(5 citation statements)

References 19 publications

(21 reference statements)

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“…The Ni(II) complexes of MIIMC, MMIIMC, and CMIIMC were discovered to be diamagnetic, with two bands about 17027-19980 cm-1 and another around 27050-27777 cm-1. The band at 17,027 -19980 cm-1 corresponds to 1A1g → 1A2g, which falls within the range of a transition proposed for square planar Ni(II) complexes [12,13]. The other band that appears around 27050-27777 cm-1 in these compounds may be due to charge transfer transition.…”

Section: Magneticsupporting

confidence: 73%

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Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes

Prashanthi,

Kiranmai,

Rao

et al. 2024

AIR

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MIIMC, MMIIMC, and CMIIMC are biologically significant Schiff bases formed by the condensation of 3-amino-5-methyl isoxazole with formyl chromone. Substituted formyl chromones and metal chelates containing Cu(II), Ni(II), Co(II), and Zn(II) are prepared. These were studied utilising elemental analysis, FTIR, UV-VIS, 1H, 13C, mass spectra, magnetic susceptibility, conductance tests, and thermogravimetric techniques. The data revealed that the ligands display neutral, bidentate coordination through carbonyl oxygen and azomethine nitrogen. The antibacterial activity of the ligands and metal complexes is determined in vitro against bacteria and fungus using the paper disc method. Metal chelates have significantly higher MIC values against bacteria than ligands. The DNA binding properties of Cu(II) complexes were examined. MTT is used to determine the complexes' anticancer efficacy against HL60 tumour cells. The researchers discovered that the complexes prevented apparent morphological alterations. The inhibition ratio was hastened by increasing the dosage, and it had a strong positive association with the medicine dosage. Thermal analysis of complexes showed initial mass loss due to moisture and hydrated water molecules, followed by weight loss at 220oC due to coordinated water molecules, indicating metal oxide breakdown.

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Section: Magneticsupporting

confidence: 73%

“…These Schiff bases were also synthesized by microwave irradiation and ultrasonic methods 5a,5b . The products obtained were highly pure with good yield compared to the ligands prepared by conventional methods [10][11][12].…”

Section: Synthesis Of Ligands: Miimc / Mmiimc / Cmiimcmentioning

confidence: 93%

Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes

Prashanthi,

Kiranmai,

Rao

et al. 2024

AIR

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“…1,3 In recent years, the study of isatin-derived Schiff base metal complexes has received much attention. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Amongst them, copperĲII) complexes of the Schiff base ligands derived from isatin and different amines have received much more attention, mainly because of their potential anticancer properties. The copperĲII) complexes of the Schiff bases, obtained by the condensation of different amines and isatin, were prepared and characterized using spectroscopic means.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper(ii) complexes

et al. 2016

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“…Antimicrobial 13 , antiviral, 14,15 inhibitors of Methionine Aminopeptidase-2, 16 Anhydrase inhibitors, 17 anti-cancer 18 , antiinflammatory, 19 inhibitors of the HIV-1, 20 analgesic 21 and antioxidant 22 .As well the compounds of Schiff base derivatives displayed broader properties and applications such as nonlinear optical devices 23 liquid crystalline 24,25 , dyes 26 , biological [27][28][29] and pharmaceutical 30 applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Ability of New 5-amino-1,2,4-Triazole Derivatives Containing 2,6-dimethoxyphenol

Hussain¹

2016

Orient. J. Chem

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4-amino-3-(4-(((4-hydroxy-3,5dimethoxybenzyl)oxy)methyl)phenyl)-1,2,4-triazole-5-thione was synthesized by to method the first one from melt reaction of 4-(((4-hydroxy-3,5-dimethoxybenzyl) oxy)methyl)benzoic acid with Thiocarbonyldihydrazide, the second method from convert the corresponded acid hydrazide to potassium 2-(4-(((4-hydroxy-3,5-dimethoxybenzyl)oxy)methyl) benzoyl)hydrazinecarbodithioate salt then react with hydrazine hydrate. Newly Schiff base (7a-7f) were synthesized from reaction the 4-amino-1,2,4-triazol with substituted hydroxybenzaldehyde. The resulting compounds were characterized by IR, 1 H-NMR, 13 C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to screened the antioxidant properties of the synthesized compounds. Compounds 7d , 7e and 7f exhibited significant free-radical scavenging ability in both assays.

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Synthesis, Characterization and Antimicrobial Activities of 1,2,4-Triazole /Isatin Schiff bases and their Mn(II), Co(II) complexes

Cited by 5 publications

References 19 publications

Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes

Preparation, Characterization, and Biological Assessment of Heterocyclic Schiff Base Metal Complexes

Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper(ii) complexes

Synthesis and Antioxidant Ability of New 5-amino-1,2,4-Triazole Derivatives Containing 2,6-dimethoxyphenol

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