Synthesis, characterization, and optimization of Co-, Mn-, and Zn-substituted ferrite nanoparticles and nanoclusters for cancer theranostic applications

Bakhshi, Behzad; Labbaf, Sheyda

doi:10.1007/s13204-022-02421-w

Cited by 3 publications

(2 citation statements)

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“…The cancer has become one of the leading causes of death worldwide [1,2], prompting extensive research and studies aimed at developing novel treatment and diagnostic techniques. Although conventional therapies such as surgery, radiotherapy, and chemotherapy have improved cancer patients' survival and quality of life, these treatments often have significant side effects [3,4]. These are limited in their effectiveness for advanced and metastatic tumors [5,6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Valente-Rodrigues¹,

Caraballo-Vivas²,

Santos³

et al. 2023

Phys. Scr.

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Controlling the Curie temperature (TC) in the range from 42-46 °C in magnetic hyperthermia (MH) therapy is an essential research topic because overheating can cause irreversible damage to healthy tissue. When TC is in the above temperature range, the magnetic nanoparticles reach a paramagnetic state, effectively turning off the MH treatment. In this work, we synthesized Zn-Co nanoparticles of representative composition Zn0.54Co0.46CrxFe2-xO4, where the Fe3+ cations are carefully replaced by Cr3+ ions, which allow a precise tuning of TC and hence the self-regulation of MH. The X-ray diffraction analysis of the prepared nanoparticles confirms the formation of a single-phase cubic spinel structure. The average crystallite of the nanoparticles increases with Cr3+ doping, while the TC and saturation magnetization decrease considerably from 78 °C (x = 1) to 27 °C (x = 0.6) and 46.6 emu/g (x = 1) to 15.3 emu/g (x = 0.6), respectively. Besides MH potential of the investigated samples as revealed from specific absorption rate (SAR) assays and the maximum temperature reach (Tmax), vary from 7 W/g and 37.3 °C, for x = 0.6, to 38 W/g and 62.9 °C, for x = 0.1, we found that the composition Zn0.54Co0.46Cr0.4Fe1.6O4 is more promising with SAR of 22 W/g and Tmax = 42.3 °C, which is precisely lies in the safe temperature range to automatically activate the self-regulation during the magnetic hyperthermia treatment. The results reveal an excellent combination between size distribution and Cr3+ content in Zn-Co-based ferrite, which has a great potential for self-regulated magnetic hyperthermia applications.

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Section: Introductionmentioning

confidence: 99%

Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Valente-Rodrigues¹,

Caraballo-Vivas²,

Santos³

et al. 2023

Phys. Scr.

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“…For example, glycosylated surface modifications can enable the recognition of the particles and their uptake by Kupffer cells in liver, leading to livertargeted delivery [153]. However, the effects of multifunctional NPs in vivo are mainly related to their toxicity and immunogenicity [154]. Toxicity is one of the major limiting factors of the application of NPs, as excessive toxicity may lead to side effects and adverse reactions.…”

Section: Multifunctional Nanoparticlesmentioning

confidence: 99%

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Wu¹,

Zhang²,

He³

et al. 2023

Nano Biomedicine and Engineering

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Liver disease is a significant global health issue that affects the liver and contributes to approximately 2 million deaths worldwide each year. Although treatment options including surgery and medication are available, effective treatment remains a challenge because of limitations of the traditional drug-delivery methods, such as uneven and nonspecific drug distribution, which lead to negative effects on healthy tissues and a reduction in drug bioavailability. Nanotechnology provides a promising solution for targeted drug delivery to the liver, which has unique anatomical and physiological structures that render it an ideal target for nanomedicine. Several categories of nanomaterials, including inorganic nanomaterials, polymer nanomaterials, and multifunctional nanoparticles (NPs), have been studied as potential agents for targeting this organ in the context of liver diseases. Using surface modification and functionalization, nanomaterials can be selectively targeted to liver tissue or hepatocytes, thus delivering drugs, and enhancing their efficacy while minimizing their side effects. Nanomaterials exhibit numerous benefits; however, their stability and toxicity pose potential risks to living organisms result in adverse effects, such as protein adsorption, and inflammation. Despite the challenges inherent to the development of nanomaterials, ongoing research and development have a great potential for the liver-targeted treatment of liver diseases through the use of nanotechnology. In this review, we first describe the nanomaterials used to target liver diseases, i.e., metallic NPs, ceramic nanomaterials, micelles, polysaccharides, liposomes, dendrimers, carbon nanotubes, and multifunctional NPs. Moreover, the mechanisms for nanomaterials target liver disease are discussed. Finally, this review discusses the current challenges and prospects for future research directions in this field.

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Preparation, physicochemical characterization, and AC induction heating properties of colloidal aggregates of ferrimagnetic cobalt ferrite nanoparticles coated with a bio-compatible polymer

Anila

Lahiri

John³

et al. 2023

Ceramics International

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Synthesis, characterization, and optimization of Co-, Mn-, and Zn-substituted ferrite nanoparticles and nanoclusters for cancer theranostic applications

Cited by 3 publications

References 61 publications

Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Preparation, physicochemical characterization, and AC induction heating properties of colloidal aggregates of ferrimagnetic cobalt ferrite nanoparticles coated with a bio-compatible polymer

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Synthesis, characterization, and optimization of Co-, Mn-, and Zn-substituted ferrite nanoparticles and nanoclusters for cancer theranostic applications

Cited by 3 publications

References 61 publications

Investigation of Cr3+ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Investigation of Cr3+ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Nanomaterials for Targeting Liver Disease: Research Progress and Future Perspectives

Preparation, physicochemical characterization, and AC induction heating properties of colloidal aggregates of ferrimagnetic cobalt ferrite nanoparticles coated with a bio-compatible polymer

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Product

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Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications

Investigation of Cr³⁺ doped Zn-Co nanoferrites as potential candidate for self-regulated magnetic hyperthermia applications