Synthesis, Characterization and &lt;I&gt;In&lt;/I&gt; &lt;I&gt;Vitro&lt;/I&gt; Study of Curcumin-Functionalized Citric Acid-Capped Magnetic (CCF) Nanoparticles as Drug Delivery Agents in Cancer

Wani, Kirtee; Kitture, Rohini; Ahmed, Anansa S.; Choudhari, Amit; Koppikar, Soumya J.; Kale, S. N.; Kaul-Ghanekar, Ruchika

doi:10.1166/jbns.2011.1041

Cited by 18 publications

(15 citation statements)

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“…The internalization of CPGF NPs into the cells was qualitatively evaluated by Prussian blue staining as described previously [26] . MDAMB231 and MCF7 were seeded on coverslips in 6-well plates at a seeding density of 1×10 5 cells/ml.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization and In Vitro Study of Biocompatible Cinnamaldehyde Functionalized Magnetite Nanoparticles (CPGF Nps) For Hyperthermia and Drug Delivery Applications in Breast Cancer

et al. 2014

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Cinnamaldehyde, the bioactive component of the spice cinnamon, and its derivatives have been shown to possess anti-cancer activity against various cancer cell lines. However, its hydrophobic nature invites attention for efficient drug delivery systems that would enhance the bioavailability of cinnamaldehyde without affecting its bioactivity. Here, we report the synthesis of stable aqueous suspension of cinnamaldehyde tagged Fe3O4 nanoparticles capped with glycine and pluronic polymer (CPGF NPs) for their potential application in drug delivery and hyperthermia in breast cancer. The monodispersed superparamagnetic NPs had an average particulate size of ∼20 nm. TGA data revealed the drug payload of ∼18%. Compared to the free cinnamaldehyde, CPGF NPs reduced the viability of breast cancer cell lines, MCF7 and MDAMB231, at lower doses of cinnamaldehyde suggesting its increased bioavailability and in turn its therapeutic efficacy in the cells. Interestingly, the NPs were non-toxic to the non-cancerous HEK293 and MCF10A cell lines compared to the free cinnamaldehyde. The novelty of CPGF nanoparticulate system was that it could induce cytotoxicity in both ER/PR positive/Her2 negative (MCF7) and ER/PR negative/Her2 negative (MDAMB231) breast cancer cells, the latter being insensitive to most of the chemotherapeutic drugs. The NPs decreased the growth of the breast cancer cells in a dose-dependent manner and altered their migration through reduction in MMP-2 expression. CPGF NPs also decreased the expression of VEGF, an important oncomarker of tumor angiogenesis. They induced apoptosis in breast cancer cells through loss of mitochondrial membrane potential and activation of caspase-3. Interestingly, upon exposure to the radiofrequency waves, the NPs heated up to 41.6°C within 1 min, suggesting their promise as a magnetic hyperthermia agent. All these findings indicate that CPGF NPs prove to be potential nano-chemotherapeutic agents in breast cancer.

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Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization and In Vitro Study of Biocompatible Cinnamaldehyde Functionalized Magnetite Nanoparticles (CPGF Nps) For Hyperthermia and Drug Delivery Applications in Breast Cancer

et al. 2014

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“…For TEM characterization highly diluted specimens were prepared and dilution level was kept constant for all samples. Toxicity analysis was done using MTT assay as described elsewhere [31]. and C\O\C (1000-1300 cm −1 ) typically attributed to symmetric and asymmetric configurations of C\O\C chains [11].…”

Section: Characterizationmentioning

confidence: 99%

Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability

Gangwar

Dhumale

Kumari

et al. 2012

Materials Science and Engineering: C

134

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“…25 Many reports of curcumin conjugation with Fe 3 O 4 nanoparticles have been reported in literature with an additional linker to modify the nanoparticle surface with curcumin; however, a direct functionalization in single step without any linkers and additional reaction steps has not been reported to date. 25,34 …”

Section: Introductionmentioning

confidence: 99%

Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles

Bhandari

Gupta

Dziubla

et al. 2016

Materials Science and Engineering: C

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Magnetic iron oxide nanoparticles have been well known for their applications in magnetic resonance imaging (MRI), hyperthermia, targeted drug delivery, etc. The surface modification of these magnetic nanoparticles has been explored extensively to achieve functionalized materials with potential application in biomedical, environmental and catalysis field. Herein, we report a novel and versatile single step methodology for developing curcumin functionalized magnetic Fe3O4 nanoparticles without any additional linkers, using a simple coprecipitation technique. The magnetic nanoparticles (MNPs) were characterized using transmission electron microscopy, x-ray diffraction, fourier transform infrared spectroscopy and thermogravimetric analysis. The developed MNPs were employed in a cellular application for protection against an inflammatory agent, a polychlorinated biphenyl (PCB) molecule.

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Synthesis, Characterization and <I>In</I> <I>Vitro</I> Study of Curcumin-Functionalized Citric Acid-Capped Magnetic (CCF) Nanoparticles as Drug Delivery Agents in Cancer

Cited by 18 publications

References 0 publications

Synthesis, Characterization and In Vitro Study of Biocompatible Cinnamaldehyde Functionalized Magnetite Nanoparticles (CPGF Nps) For Hyperthermia and Drug Delivery Applications in Breast Cancer

Synthesis, Characterization and In Vitro Study of Biocompatible Cinnamaldehyde Functionalized Magnetite Nanoparticles (CPGF Nps) For Hyperthermia and Drug Delivery Applications in Breast Cancer

Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability

Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles

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