Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles

Abstract

Magnetic iron oxide nanoparticles have been well known for their applications in magnetic resonance imaging (MRI), hyperthermia, targeted drug delivery, etc. The surface modification of these magnetic nanoparticles has been explored extensively to achieve functionalized materials with potential application in biomedical, environmental and catalysis field. Herein, we report a novel and versatile single step methodology for developing curcumin functionalized magnetic Fe3O4 nanoparticles without any additional linkers, using a simple coprecipitation technique. The magnetic nanoparticles (MNPs) were characterized using transmission electron microscopy, x-ray diffraction, fourier transform infrared spectroscopy and thermogravimetric analysis. The developed MNPs were employed in a cellular application for protection against an inflammatory agent, a polychlorinated biphenyl (PCB) molecule.

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

“…[72] Their investigation from in vitro tests on two human cancer cells showed the easy penetration of the resultant MNPs into cell cytoplasm in the living cells to be very promising for bio-imaging applications. In a very recent study performed by Bhandari et al, [73] a simple coprecipitation method was used to produce curcumin functionalized magnetite nanoparticles and they were analyzed for cell viability assay against an inflammatory agent. Pereira et al [74] prepared small sized ferrites by using alkanolamines as the alkaline source and as complexing agents which resulted in better magnetic properties.…”

Biopolymeric Nanoparticle Synthesis in Ionic Liquids

“…In an attempt to enhance the therapeutic efficiency of curcumin, improvements in its bioavailability have been tried. Several nanocarriers such as solid lipid nanoparticles [62], natural [63] or synthetic [64] polymer nanoparticles, and inorganic nanoparticles [65] can be found in the study as examples of nanoplatforms for the intracellular delivery of curcumin. Recently, research interests focus on the use of biopolymers such as SF to encapsulate curcumin and other similar drugs [66].…”

Recent advances on iron oxide magnetic nanoparticles as sorbents of organic pollutants in water and wastewater treatment

“…Recently, our group has described a novel and versatile one step coprecipitation synthesis methodology of curcumin stabilized iron oxide magnetic nanoparticles (C-IO MNPs), shown in Figure 2A, that can potentially be used in environmental remediation, biomedical and catalysis applications (35). Curcumin is a naturally occurring antioxidant and polyphenol found in the Indian spice turmeric, with a high content of aromatic groups in its molecular structure (36,37).…”

“…The presence of these groups offers the possibility of interaction through pi-pi sticking with similar molecules, such as PCBs, in a variety of environments. Bhandari et al (35) demonstrated successful incorporation of the curcumin onto the surface of the IONPs, representing around 10-12% in mass of the nanoparticle's weight. The C-IO MNPs showed a 10-fold increase in safe administration limits compared to uncoated IONPs when incubated for 24 h with human umbilical vein endothelial cells (HUVECs), thanks to the antioxidant response of curcumin.…”