Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes

Abstract

Abstract:A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

“…The remaining of these bands unaltered, confirms the inertness of N-* N active sites towards coordination[20]. The presence of hydrated water in the Pt(II) complex is confirmed by the presence of bands at 3431, 746 and 690 cm -1 due to  (OH),  (OH) and  w (OH), respectively[27,28,29]. New weak bands are observed at 557 and 449 cm-1 due to ν (M-O), ν (M-N) respectively [20].…”

“…The last step starts from 461˚C to 880˚C, corresponding to the loss four hydrocyanic acid molecules (Found mass loss of this step is 8.7%; Calcd 9.0%). (3) (Where, Z, h and K are the pre-exponential factor, Plank and Boltzmann constants, respectively [28]. The thermodynamic parameters were calculated for the second step, which is suitable for kinetic analysis, where there is no overlapping with other steps.…”

Mn(II), Co(II), Ni(II), and Cu(II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations

“…The bands seen in range 1595-1546 cm -1 were new and are assigned to υ(CH=C) vibration [14]. The Schiff base behaves as a tridentate as the results indicates, coordinating to the enol form of the acac oxygen, azomethine nitrogen and 2).…”

“…The metal complexes spectra display bands from acac. The bands seen in range 1595 vibration [14]. The Schiff base behaves as a the central metals through the enol fo carboxylate oxygen (Figure 2).…”

“…It was suggested that atoms of amino acid will hold in the plane of the aromatic ring when they are coordinated to the metal ions [12]. Metal complexes derived from amino acids have attracted much more attention because of its inorganic and biological importance [13][14][15]. They show wide applications as anti-cancer, anti-tumor, anti-bacterial, anti-fungal, and anti-inflammatory agents [15][16][17].…”