Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.
Abstract:A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.
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