Synthesis, characterization and in vitro antimicrobial evaluation of new glycosyl imidothiocarbamates

Abstract

A series of new glycosyl imidothiocabamates were synthesized and charaterized and their antimicrobial properties were evaluated. These compounds were synthesized by the condensation of per-O-acetyl lactosyl isocyanate with N-aryl-S-benzyl isothiourea and per-O-benzoyl glucosyl aryl isothiourea and characterised using the IR, 1 H NMR, and mass spectroscopy and elemental analysis. The synthesized compounds were screened for their in vitro antimicrobial activity against bacteria (S. aureus, E. coli, P. vulgaris, P. aeruginosa) and fungi (A. niger, Penicillium). Some of these compounds exhibited moderate to good activity, whereas some were inactive.