Synthesis and Antimicrobial Studies of Novel N-Glycosyl Hydrazino Carbothioamide

Abstract

In view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, herein the synthesis of novel N-glycosyl hydrazino carbothioamides is reported. New N-glycosyl hydrazino carbothioamides were synthesized by the condensation of per-O-acetyl glycosyl isothiocyanate with different aromatic hydrazides. The newly synthesized compounds were characterized by using the IR, 1H NMR and mass spectral studies. Antimicrobial evaluation of the synthesized N-glycosyl hydrazino carbothioamide was also examined. Antimicrobial activities of the synthesized compound were evaluated against bacteria E. coli, P. aeruginosa, S. aureus, S. pyogenus and fungi C. albicans, A. niger and A. clavatus. All the N-glycosyl hydrazino carbothioamides exhibit promising antimicrobial activity.

Relevant Advances in the Synthesis and Applications of N‐Glycopyranosides

“…Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of N ‐glycosides derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention because of their potential biological properties [41,42] . Hence, due to applications of N ‐glycosylated compounds in medicinal chemistry, Mangte et al.…”

“…The glycosyl isothiocyanates have been the focus of synthetic attention because of their potential biological properties. [41,42] Hence, due to applications of N-glycosylated compounds in medicinal chemistry, Mangte et al report the synthesis and antimicrobial studies of novel glycosyl thiocarbamides of amino tetrazole and aminopyrimidine. [43] A procedure for the synthesis of compounds 63 and 64 from N-glycooxazoline 62 precursors was proposed by Blanco and collaborators.…”