Synthesis, characterization andin vitroantimicrobial evaluation of new compounds incorporating oxindole nucleus

Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

“…The plates were kept at room temperature for 1-2 h, then incubated at 37°C for 24 h for bacteria and at 30 °C for 4 days for fungi. Commercial antibiotic discs were used as positive reference standard to determine the sensitivity of the strains [25].…”

Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

“…As part of our ongoing studies concerning the preparation of potential biologically active compounds [24][25][26][27][28][29] and bioactive heterocycles based on oxindole moiety [30][31][32][33][34][35] , we report herein a convenient microwave-enhanced, high speed, fast, and economic way for the synthesis of new 2(3H)-furanones, for use as key intermediates for the synthesis of new pyridazine, pyrrol, and sulfonamide derivatives.We investigated their antimicrobial activity in…”

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

“…Microwave technology is particularly suitable for the rapid and automated production of heterocyclic libraries [24][25][26][27][28][29][30] . In this study, we have synthesized hydrazine derivatives and three different classes of bis-Schiff bases.…”

“…Hence it was considered that combinations of indole and 1,2,4-triazole structures might provide more potent pesticides 23 . In continuation of our studies on the synthesis and evaluation of biological activity of new heterocycles [24][25][26][27][28][29][30] , we report herein the efficient synthesis of new hydrazones, and Schiff bases based on the indole moiety and the evaluation of their biological activity as antimicrobial and anticancer agents.…”