Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy

Yi, Tianqi; Huang, Jun; Chen, Xuewen; Xiong, Haiyun; Kang, Yang; Wu, Jun

doi:10.1039/c9bm00111e

Cited by 22 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Puerarin is widely used in the treatment of vascular disease, diabetes and Parkinson's disease. 20,21 Moreover, puerarin administration dose-dependently and time-dependently induced cell apoptosis, which supported its use as an anticancer agent for various tumors. 22,23 Previous investigations and our study indicated that puerarin increased mitochondria-mediated apoptosis to inhibit cancer cell proliferation in vitro and in vivo, 24 which was the predominant contributor to ovarian cancer cell death.…”

Section: Discussionmentioning

confidence: 92%

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

et al. 2021

View full text Add to dashboard Cite

Objective Previous investigations indicated the anticancer activity of puerarin. The current study aimed to evaluate the effect and molecular mechanisms of puerarin in chemotherapy-resistant ovarian cancer cells. Methods We examined the effects of puerarin in platinum-resistant epithelial ovarian cancer cells in vitro and in vivo. We also analyzed the molecular mechanism underlying Wnt/β-catenin inhibition and sirtuin 1 (SIRT1) regulation following puerarin treatment. Results Our study demonstrated that puerarin effectively inhibited cell growth in vitro and in vivo by increasing apoptosis in ovarian cancer cells. More importantly, puerarin sensitized cisplatin-resistant ovarian cancer cells to chemotherapy. Puerarin treatment decreased SIRT1 expression, which attenuated the nuclear accumulation of β-catenin to inhibit Wnt/β-catenin signaling. In addition, SIRT1 overexpression diminished the effects of puerarin treatment on cisplatin-resistant ovarian cancer cells. Further analysis supported SIRT1/β-catenin expression as a candidate biomarker for the disease progression of epithelial ovarian cancer. Conclusions Puerarin increased the apoptosis of platinum-resistant ovarian cancer cells. The mechanism is partly related to the downregulation of SIRT1 and subsequent inhibition of Wnt/β-catenin signaling.

show abstract

Section: Discussionmentioning

confidence: 92%

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The preparation of more biocompatible nanocarriers from modified natural materials has become a research hotspot in recent years. Puerarin was modified with unsaturated alkene by allyl chloride, and finally the amphiphilic polymer polypuerarin was acquired by free radical polymerization, which was utilized in the preparation of a drug release system [ 185 ]. Puerarin is an herbaceous natural product that self-assembles to form pH-sensitive hydrogel without any structural modification.…”

Section: A New Drug Delivery System For Puerarinmentioning

confidence: 99%

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Wang

et al. 2022

Antioxidants

View full text Add to dashboard Cite

As a kind of medicine and food homologous plant, kudzu root (Pueraria lobata (Willd.) Ohwi) is called an “official medicine” in Chinese folk medicine. Puerarin is the main active component extracted from kudzu root, and its structural formula is 8-β-D-grapes pyranose-4, 7-dihydroxy isoflavone, with a white needle crystal; it is slightly soluble in water, and its aqueous solution is colorless or light yellow. Puerarin is a natural antioxidant with high health value and has a series of biological activities such as antioxidation, anti-inflammation, anti-tumor effects, immunity improvement, and cardio-cerebrovascular and nerve cell protection. In particular, for the past few years, it has also been extensively used in clinical study. This review focuses on the antioxidant activity of puerarin, the therapy of diverse types of inflammatory diseases, various new drug delivery systems of puerarin, the “structure-activity relationship” of puerarin and its derivatives, and pharmacokinetic and clinical studies, which can provide a new perspective for the puerarin-related drug research and development, clinical application, and further development and utilization.

show abstract

“…Acryloyl chloride is a pale‐yellow, highly toxic volatile liquid acrylating agent with a molecular formula of C 3 H 3 CLO, used in the synthesis of biomaterials. 1 , 2 It can cause irritation to the eyes and other mucosal surfaces, pneumonia, pulmonary edema, and even death. However, to the best of our knowledge, only one published report describes patients exposed to this substance.…”

Section: Introductionmentioning

confidence: 99%

“…Acryloyl chloride is a pale‐yellow, highly toxic volatile liquid acrylating agent with a molecular formula of C 3 H 3 CLO, used in the synthesis of biomaterials 1,2 . It can cause irritation to the eyes and other mucosal surfaces, pneumonia, pulmonary edema, and even death.…”

Section: Introductionmentioning

confidence: 99%

Acute respiratory distress syndrome due to inhalation of acryloyl chloride

Shima

Kashiwagi

Ino

et al. 2022

Acute Medicine & Surgery

View full text Add to dashboard Cite

Background Acryloyl chloride is a highly toxic volatile liquid that can cause pulmonary edema. However, no sufficient treatment reports have been published to date. Here, we report a case of acute respiratory distress syndrome (ARDS) caused by acryloyl chloride inhalation. Case presentation The patient was a 36‐year‐old man with accidental exposure to acryloyl chloride. The patient had dyspnea and wet cough, with approximately 88% percutaneous oxygen saturation at room air. He was diagnosed with ARDS and admitted to the intensive care unit. Initially, he was treated with a high‐flow nasal cannula and sivelestat sodium. However, due to the possibility of delayed exacerbation, the patient was switched to methylprednisolone. Oxygenation gradually improved, and the patient was discharged on the day 8 of hospitalization. Conclusion We report the case of a patient who developed ARDS with delayed exacerbation after the inhalation of acryloyl chloride, which was treated without endotracheal intubation.

show abstract

Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy

Abstract: Poly-puerarin, a novel biodegradable biomaterial as a drug delivery platform in anti-tumour therapy.

Cited by 22 publications

References 47 publications

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Acute respiratory distress syndrome due to inhalation of acryloyl chloride

Contact Info

Product

Resources

About