Acute respiratory distress syndrome due to inhalation of acryloyl chloride

Shima, Takafumi; Kashiwagi, Hideki; Ino, Haruka; Tanaka, Suguru; Fukuda, Makiko; Kobata, Hitoshi

doi:10.1002/ams2.724

Cited by 3 publications

(17 citation statements)

References 13 publications

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“…Our entire research team was waiting outside the emergency ward, and in the meantime, I began searching for previously published cases involving acryloyl chloride accidents. Shima et al reported “acute respiratory distress (ARDS) syndrome” due to acryloyl chloride inhalation in a 36 year-old man who was accidentally exposed to the acryloyl chloride . He was admitted to the intensive care unit (ICU) after being diagnosed with ARDS.…”

Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

“…Due to the possibility of a delayed exacerbation, he was later switched to methylprednisolone. The patient’s oxygenation gradually improved, and he was discharged on the eighth day of his hospitalization . I became more concerned after reading the Lau et al report, in which he reported three cases of direct inhalation of acryloyl chloride (96%) and methacrylic anhydride (94%) .…”

Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

“…I had discussed these previously reported cases and the SDS of acryloyl chloride with Dr. Dighore. , To investigate the breathing issue, he measured her blood oxygen saturation, which was found to be normal (96 SpO 2 ), and he said that there was no breathing-related issue with her and that everything would be fine. The chest X-ray confirmed that there were no signs of pulmonary edema (Figure S3).…”

Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

“…With this context in mind, here we are reporting a laboratory accident of acryloyl chloride, its consequences, treatments, and safety measures. To the best of our knowledge, this is the third report on the acryloyl chloride accident. , Acryloyl chloride is a pale yellow, highly toxic, volatile liquid that is used in the synthesis of irreversible inhibitors and biomaterials . It can cause eye and mucosal surface irritation, pneumonia, pulmonary edema, and even death .…”

Section: Introductionmentioning

confidence: 99%

“…It can cause eye and mucosal surface irritation, pneumonia, pulmonary edema, and even death . According to the previous two reports, victims suffered from non-cardiogenic pulmonary edema, mild sore throat, eye discomfort, and acute respiratory distress syndrome (ARDS). , In our case, we noticed eye discomfort, nausea and vomiting, nose bleeding, and stomach ulceration. Nose bleeding and stomach ulcers were two distinct hazardous effects reported by the victim, which were not mentioned in the SDS of acryloyl chloride (Figures – ).…”

Section: Introductionmentioning

confidence: 99%

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A Laboratory Accident of Acryloyl Chloride, Its Consequences, Treatment, and Safety Measures: An Arduous Lesson to All Researchers

Pathan

Ahmad

Girase

et al. 2022

ACS Chem. Health Saf.

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Research and teaching have an array of unique hazards that reflects both the variety and continuous evaluation of their operation. These include technical, physical, chemical, or biological hazards. We are reporting a laboratory accident involving acryloyl chloride (chemical hazard), its consequences, safety precautions, and the lesson learned from this incident. Acryloyl chloride is a highly toxic and volatile liquid. After being accidentally exposed to acryloyl chloride, a victim experienced blackout, headache, dizziness, tiredness, nose bleeding, persistent burning of the eyes, and intense nausea and vomiting. A victim reported two distinct hazardous effects, namely, nose bleeding and stomach ulcers, which were not mentioned in the SDS of acryloyl chloride. To avoid further exacerbation of consequences of acryloyl chloride accident, it may be preferable to initiate steroidal therapy along with symptomatic treatment from the start. The accidental consequences and lessons learned from this tragedy will serve as guiding factors for research scholars, postdoctoral fellows, principal investigators (PI), safety professionals, institutions, occupational health nurses, physicians, and toxicologists to prevent anything similar from happening again in the future.

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Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

Section: Post-accident Analysis (Post-accident Incidences Diagnosis A...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Laboratory Accident of Acryloyl Chloride, Its Consequences, Treatment, and Safety Measures: An Arduous Lesson to All Researchers

Pathan

Ahmad

Girase

et al. 2022

ACS Chem. Health Saf.

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Sensing Performance of Heptazine-Based C3N4 Quantum Dot Toward Highly Toxic Environmental Pollutants, Amides, and Acetyl Derivatives

Asif¹,

Qureshi²,

Sajid³

et al. 2023

J Inorg Organomet Polym

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A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

et al. 2023

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Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) and fibrosis. The limited number of FDA-approved inhaled drugs for these serious lung conditions has led to a shift from in vivo towards the use of alternative in vitro human-relevant models to better predict the toxicity of inhaled particles in preclinical research. While there are several inhalation exposure models for the upper airways, the fragile and dynamic nature of the alveolar microenvironment has limited the development of reproducible exposure models for the distal lung. Here, we present a mechanistic approach using a new generation of exposure systems, the Cloud α AX12. This novel in vitro inhalation tool consists of a cloud-based exposure chamber (VITROCELL) that integrates the breathing AXLung-on-chip system (AlveoliX). The ultrathin and porous membrane of the AX12 plate was used to create a complex multicellular model that enables key physiological culture conditions: the air-liquid interface (ALI) and the three-dimensional cyclic stretch (CS). Human-relevant cellular models were established for a) the distal alveolar-capillary interface using primary cell-derived immortalized alveolar epithelial cells (AXiAECs), macrophages (THP-1) and endothelial (HLMVEC) cells, and b) the upper-airways using Calu3 cells. Primary human alveolar epithelial cells (AXhAEpCs) were used to validate the toxicity results obtained from the immortalized cell lines. To mimic in vivo relevant aerosol exposures with the Cloud α AX12, three different models were established using: a) titanium dioxide (TiO2) and zinc oxide nanoparticles b) polyhexamethylene guanidine a toxic chemical and c) an anti-inflammatory inhaled corticosteroid, fluticasone propionate (FL). Our results suggest an important synergistic effect on the air-blood barrier sensitivity, cytotoxicity and inflammation, when air-liquid interface and cyclic stretch culture conditions are combined. To the best of our knowledge, this is the first time that an in vitro inhalation exposure system for the distal lung has been described with a breathing lung-on-chip technology. The Cloud α AX12 model thus represents a state-of-the-art pre-clinical tool to study inhalation toxicity risks, drug safety and efficacy.

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Acute respiratory distress syndrome due to inhalation of acryloyl chloride

Cited by 3 publications

References 13 publications

A Laboratory Accident of Acryloyl Chloride, Its Consequences, Treatment, and Safety Measures: An Arduous Lesson to All Researchers

A Laboratory Accident of Acryloyl Chloride, Its Consequences, Treatment, and Safety Measures: An Arduous Lesson to All Researchers

Sensing Performance of Heptazine-Based C3N4 Quantum Dot Toward Highly Toxic Environmental Pollutants, Amides, and Acetyl Derivatives

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

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