Synthesis, characterization and crystal structure of cobalt(III) complexes containing 2-acetylpyridine thiosemicarbazones: DNA/protein interaction, radical scavenging and cytotoxic activities

Manikandan, R.; Viswanathamurthi, Periasamy; Velmurugan, K.; Nandhakumar, Raju; Hashimoto, Takeshi; Endo, Akira

doi:10.1016/j.jphotobiol.2013.11.008

Cited by 76 publications

(32 citation statements)

References 60 publications

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“…Three bands, at 222, 296 and 354 nm, can be assigned to intra ligand n→π * transitions of the azomethine portion and π→π * transitions of the aromatic ring, while band at 422 nm was assigned to the ligand to metal charge transfer transition. The same number of bands and distribution of their intensities was found for similar Co(III) complex with 2acetylpyridine thiosemicarbazone 33. The aqueous solution behavior of 1 with respect to hydrolysis was studied in DMSO/H 2 O 1:100 (v/v) solution at ambient temperature over 24 h by UV-Vis spectroscopy.…”

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confidence: 54%

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

Filipović

Bjelogrlić²,

Portalone

et al. 2016

Med. Chem. Commun.

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confidence: 54%

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

Filipović

Bjelogrlić²,

Portalone

et al. 2016

Med. Chem. Commun.

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“…Manikandan et al [36] have reported the Co(II) complexes of 2-acetylpyridine N-substituted thiosemicarbazone with (PPh3)2 (Fig. 27).…”

Section: Introductionmentioning

confidence: 99%

Schiff Base Metal Complexes as Anticancer Agents

Sridevi

Antony

R³

2019

Asian J. Chem.

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Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

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“…Manikandan et al . reported three cobalt complexes containing 2‐acetylpyridine thiosemicarbazones, which showed higher activity and efficiently eliminated cancer cells even at low concentrations . Additionally, cobalt is less toxic to humans than non‐essential metals like platinum, which has prompted researchers to study cobalt‐containing compounds as less toxic alternatives to platinum‐based anticancer drugs .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

Zhang

Meng

Liu

et al. 2016

Applied Organom Chemis

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A new cobalt(II) complex (1) of 5‐chloro‐8‐hydroxyquinoline was prepared and structurally characterized using infrared spectroscopy, electrospray ionization mass spectrometry, elemental analysis, single‐crystal X‐ray diffraction as well as powder X‐ray diffraction. Its biological activities including DNA binding and anticancer activity were investigated. The DNA binding study of complex 1 suggested that it interacted with calf thymus DNA mainly via an intercalative binding mode. The in vitro anticancer activity of complex 1 was screened against a series of tumor cell lines as well as the normal liver cell line HL‐7702 using MTT assay. complex 1 showed much higher cytotoxicity than corresponding metal salt and ligand towards the five tested tumor cell lines, in which T‐24 was the most sensitive tumor cell line towards 1, with IC50 value of 7.04 ± 0.06 μM. complex 1 was found to greatly induce cell cycle arrest in T‐24 cells at S phase, and consequently to induce cell apoptosis in a dose‐dependent mode suggested by cell apoptosis analysis via Hoechst 33258 and acridine orange/ethidium bromide staining assays. The cell apoptosis mechanism of 1 was studied targeting the mitochondrion‐mediated pathway, since the apoptotic mechanism in the T‐24 cells treated by 1 was investigated by reactive oxygen species (ROS) detection, intracellular calcium concentration measurement and caspase‐9/3 activity assay. The results suggested that the cell apoptosis induced by 1 was closely related to the loss of mitochondrial membrane potential, ROS production and enhancement of intracellular [Ca2+], which would trigger the caspase‐9/3 activation via a mitochondrial dysfunction pathway. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Synthesis, characterization and crystal structure of cobalt(III) complexes containing 2-acetylpyridine thiosemicarbazones: DNA/protein interaction, radical scavenging and cytotoxic activities

Cited by 76 publications

References 60 publications

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

Schiff Base Metal Complexes as Anticancer Agents

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

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