Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(iii) complex in human cancer cell lines

Abstract

The ligand initiated reprogramming of cancer stem cells phenotype in AsPC-1 cells. The complex digested plasmid DNA which might be the cause of its cytotoxic activity.

Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study

“…However, the chalcogen donor atoms deviate slightly from the average planes formed by the ligands' skeleton (0.11 and 0.18 Å, respectively, for S1A and S1B in 1, and 0.06 and 0.48 Å, respectively, for Se1A and Se1B in 2) due to intramolecular repulsion. As previously noticed for the related N4 unsubstituted quinoline-based chalcogensemicarbazone complexes, 17,[45][46][47][48][49] in the crystal structure of 1 and 2, the chalcogen donors are forced by the bischelate coordination of the ligands to come closer than the sum of their van der Waals radii (1: S1A … S1B = 3.1914(8) Å, r S = 1.80 Å; 2: Se1A … Se1B = 3.3434(5) Å, r Se = 1.90 Å). All metal-donor atom bonds in both complexes are similar to the average corresponding bonds found in a search on quinoline thio/selenosemicarbazone-Co systems performed through the CSD.…”

“…Significant reduction of activity was observed for 2 in comparison to free H2qasesc. The same trend was observed in the case of 8-quinolinecarboxaldehyde selenosemicabazone (H8qsesc) and its Co(III) complex 47 as well in the case of Pd(II), Pt(II) and Zn(II) complexes with quinoline based selenosemicarbazones. 57,59 In the case of complexation of H2qatsc with Co(III), an increase in the free-radical scavenging activity was observed.…”

(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines

“…The same compound has also been shown to induce some markers of differentiation in solid tumour cancer stem cells. 56 Despite H8qaSC, H8qaTSC and H8qaSeSC having a rather similar structure with a sulphur or selenium atom substituting an oxygen atom in the parent compound H8qaSC, it appears that these small modifications greatly vary the differentiation-inducing activity of H8qaSC, with selenium enhancing it and sulphur removing it. Selenium is an important trace element in the body and the inclusion of this atom may mimic a selenium-containing natural factor.…”

“…Complex 2 is isostructural with the cobalt(III) complex with the selenium ligand [Co(8qaSeSC) 2 ]ClO 4 •DMSO (3). 56…”

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies

“…Apart from usage of selenium compounds in diseases prevention by selenium supplementation, developing of synthetic organoselenium compounds as well as their metal complexes is subject of research in the field of medicinal chemistry. The potential of synthetic selenium compounds in medicinal chemistry include antioxidant, antitumor, antiviral, antimicrobial, anti-infective, anti-inflammatory, antiparasitic, antidiabetic, antimalarial, neuroprotective, antihypersensitive, and cardiotonic agents as well as enzyme inhibitors and immunomodulators (Karvekar et al, 2007 ; Akhoon et al, 2015 ; Filipović et al, 2016 ).…”