Schiff Base Metal Complexes as Anticancer Agents

Abstract

Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

Influence of co‐ligand on the biological properties of Schiff base metal complexes: Synthesis, characterization, cytotoxicity, and antimicrobial studies

“…The Cu (II) complex showed enhanced cytotoxicity than other metal complexes from this work and is comparable with the IC 50 values of the cis-platin drug (20.2-22.4 μM) based on the literature. [76][77][78] The anticancer property of the metal complexes is depending on their DNA binding ability and causes damage/change in their structure, resulting in impairment of its function. The structural modifications/damage is followed by inhibition of replication and transcription process, eventually leading to cell death as the DNA lesions are not properly repaired.…”

Synthesis, Spectral Characterisation and Cytotoxic Evaluation of Substituted Sulfonamide Schiff Bases

“…A mitochondrial enzyme in living cells, succinate-dehydrogenase, cleaves the tetrazolium ring, converting the MTT to an insoluble purple formazan. (15,16) Therefore, the amount of formazan produced is directly proportional to the number of viable cells.…”

The N’-Substituted Derivatives of 5-Chloro-3-Methylisothiazole-4-Carboxylic Acid Hydrazide with Antiproliferative Activity

“…Crystals of 3, 4 and 8 suitable for single-crystal X-ray diffraction analysis were obtained by dissolution in acetonitrile/2-propanol followed by slow evaporation of the solvent at room temperature. Crystallographic measurements for 3, 4 and 8 were collected with K-geometry diffractometers: Xcalibur R (Agilent Technologies, city, state abbrev if USA, country) with a Ruby CCD camera (3 and 4) and a Kuma KM-4 CCD with a Sapphire2 CCD camera (8), with graphite monochromatized Mo-Kα radiation (λ = 0.71073 Å) at 100(2) K, using an Oxford Cryosystems cooler. Data collection, cell refinement, data reduction and analysis were carried out with CrysAlisPro [33].…”

“…Many studies have indicated the antitumor potential of isothiazole derivatives. CP-547.632 39, which belongs to the (3-aryl-4-carboxamido-isothiazol-3-yl)-carbamides, is a promising tyrosine kinase inhibitor with antineoplastic activity [7,8] used in the treatment of non-small cell lung cancer. CP-547.632 39 is an anti-angiogenic drug, which is effective only in combination with other cytostatics [9,10].…”