Synthesis, characterization, and application of easily accessible resin-encapsulated nickel nanocatalyst for efficient reduction of functionalized nitroarenes under mild conditions

Abstract

A novel resin-encapsulated nickel nanocatalyst has been synthesized by a modified impregnation method using nickel acetate tetrahydrate in presence of sodium borohydride as a mild reducing agent. The synthesized nanocatalyst was characterized by field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The concentration of nickel nanoparticles encapsulated on resin was determined by inductively coupled plasma-mass spectroscopy (ICP-MS). Further, synthesized resinencapsulated nickel nanocatalyst was found to be stable and efficient in micromolar concentrations, for the selective reduction of functionalized nitroarenes to corresponding amines in good to high yield, under mild reaction conditions. The nanocatalyst shows excellent reusability.

Investigation into Solubility and Solvent Effect of 2-Aminopyridine in Different Mono-Solvents Over Temperatures from 273.15 to 313.15 K

“…no., 504-29-0; structure, Figure ) is widely employed in a variety of applications of pharmaceuticals’ synthesis, especially for antihistamines, antiflammatories, and other drugs. , Brominated 2-aminopyridine attracted considerable attention for its applications as useful intermediates or building blocks for pharmaceuticals. − In particular, 2-aminopyridine also serves as an useful raw material for some liquid crystals. , Regardless of its wide applications, there has been little research into the thermodynamic properties of 2-aminopyridine in neat and mixed solvents. 2-Aminopyridine is generally obtained through the reduction of 2-nitropyridine or 2-halopyridine in various solvents such as ethanol, , methanol, acetonitrile, N -methyl-2-pyrrolidine (NMP), and so on. Therefore the solubility of 2-aminopyridine in various solvents has a significant impact on product yield.…”

“…10,11 Regardless of its wide applications, there has been little research into the thermodynamic properties of 2-aminopyridine in neat and mixed solvents. 2-Aminopyridine is generally obtained through the reduction of 2-nitropyridine or 2-halopyridine in various solvents such as ethanol, 12,13 methanol, 14 acetonitrile, 15 Nmethyl-2-pyrrolidine (NMP), 16 and so on. Therefore the solubility of 2-aminopyridine in various solvents has a significant impact on product yield.…”

Aluminum Metal–Organic Framework-Ligated Single-Site Nickel(II)-Hydride for Heterogeneous Chemoselective Catalysis

“…Generally, well-defined nickel-hydride species are afforded using multidentate strong field nitrogen- and phosphorous-donor ligands bearing sterically encumbered bulky substituents . These nickel-hydrides have been investigated as single-site homogeneous catalysts in many organic transformations such as hydrogenation, − hydroelementation, − oligomerization, ,− reduction of CO 2 , − and dehydrogenation. , In contrast, the traditional heterogeneous nickel catalysts that undergo Ni–H bond participation such as Raney nickel, resin-encapsulated nickel nanoparticles, and alumina- or silica-supported nickel − have multiple sites, leading to give poor selectivity and also complicating the delineation of active sites and reaction mechanisms. Therefore, the development of chemoselective and heterogeneous single-site nickel catalysts is essential for sustainable chemical synthesis.…”