We have developed a heterogenized catalyst of Cu(ii) complex immobilized onto nanosilica obtained from rice husk (RH), through Schiff-base condensation between 3-aminopropyltriethoxysilane (APTES) functionalized nanosilica and acetamide.

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Here we report the synthesis and characterization of graphene oxide anchored Pd–Cu bimetallic nanoparticles by bio reduction method and its application in Sonogashira cross-coupling reaction.

Malaria continues to become a major global health problem, particularly in Sub‐Saharan Africa, Asia, and Latin America. The widespread emergence of resistance to first‐line drugs has further bolstered an urgent need for a new and cost‐effective antimalarial(s). Thus, the present study enumerates the synthesis of novel hybrid dimethoxy pyrazole 1,3,5‐triazine derivatives 7(a–j) and their in silico results short‐listed three compounds with good binding energies and dock scores. Docking analysis shows that hydrogen‐bonding predominates and typically involves key residues, such as Asp54, Tyr170, Ile164, and Arg122. The in vitro antimalarial evaluation of three top‐ranked compounds (7e, 7g, and 7h) showed half‐maximal inhibitory concentration values range from 53.85 to 100 μg/ml against chloroquine‐sensitive strain 3D7 of Plasmodium falciparum. Compound 7e may be utilized as a lead for further optimization work in drug discovery due to good antimalarial activity.

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