Synthesis, Characterization and Antioxidant Activity of Cooper-Quercetin Complex and Iron-Quercetin Complex

Trifunschi, Svetlana; Munteanu, Melania

doi:10.37358/rc.18.10.6593

Cited by 8 publications

(10 citation statements)

References 9 publications

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“…Normally, plants synthesize them as a protection mechanism to environmental attack (microbial infection, UV exposure). Over the years, the flavonoids were found to play an important role on the human health due to their antimicrobial, antioxidant, antiinflammatory and anticancer properties [8][9][10][11][12].…”

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confidence: 99%

“…The increased interest in the replacement of synthetic antioxidants from food with the natural ones has supported the search of plant sources and the choice of raw materials for new antioxidants identification. Because, until now, about 10000 flavonoids have been recorded [9], the researchers have focused their work on finding relationships between flavonoids structure and their *email: mirel_glevitzky@yahoo.com; gabriela.cioca@ulbsibiu.ro All the authors have equal contribution at this original article.…”

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confidence: 99%

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Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

Glevitzky¹,

Dumitrel²,

Glevitzky³

et al. 2019

Rev. Chim.

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Using different methods of statistics, this paper aims to highlight the potential link between the antioxidant activity of flavonoids and the corresponding molecular descriptors. By calculating the descriptors (van der Waals surface (A), molar volume (V), partition coefficient (LogP), refractivity (R), polarizability (a), forming heat (Hformation), hydration energy (Ehidr), the dipole moment (mt)), together with antioxidant activities (RSA) calculated or taken from the literature, number of phenolic -OH groups and the presence (2) or absence (1) of C2=C3 double bond) for 29 flavonoid compounds and by intercorrelation between the studied parameters, the link between the number of phenolic groups grafted to the basic structure of flavonoids and their antioxidant activity was confirmed. Simultaneously, by using the chi-squared test and the intercorrelations matrix, a satisfactorily correlation coefficient (r2=0.5678; r=0.7536) between the structure of the flavonoids and their activity was obtained, fact that confirms the correlation of the antioxidant activity with the number of -OH phenolic groups.

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confidence: 99%

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confidence: 99%

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

Glevitzky¹,

Dumitrel²,

Glevitzky³

et al. 2019

Rev. Chim.

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“…The higher biological activity of metal complexes compared with ligand was reported by other authors as well. For example, Co(II), Cd(II), and Cu(II) complexes of quercetin showed a greater ability to inhibit DPPH • radical than the pure ligand [91,92]. Complexation with Mg(II) ions increased the hypoglycemic and antibacterial activity compared to luteolin alone, especially against E. coli [50].…”

Section: Anti-/pro-oxidant Studymentioning

confidence: 99%

Crystal Structure, Spectroscopic Characterization, Antioxidant and Cytotoxic Activity of New Mg(II) and Mn(II)/Na(I) Complexes of Isoferulic Acid

et al. 2021

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The Mg(II) and heterometallic Mn(II)/Na(I) complexes of isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA) were synthesized and characterized by infrared spectroscopy FT-IR, FT-Raman, electronic absorption spectroscopy UV/VIS, and single-crystal X-ray diffraction. The reaction of MgCl2 with isoferulic acid in the aqueous solutions of NaOH resulted in synthesis of the complex salt of the general formula of [Mg(H2O)6]⋅(C10H9O4)2⋅6H2O. The crystal structure of this compound consists of discrete octahedral [Mg(H2O)6]2+ cations, isoferulic acid anions and solvent water molecules. The hydrated metal cations are arranged among the organic layers. The multiple hydrogen-bonding interactions established between the coordinated and lattice water molecules and the functional groups of the ligand stabilize the 3D architecture of the crystal. The use of MnCl2 instead of MgCl2 led to the formation of the Mn(II)/Na(I) complex of the general formula [Mn3Na2(C10H7O4)8(H2O)8]. The compound is a 3D coordination polymer composed of centrosymmetric pentanuclear subunits. The antioxidant activity of these compounds was evaluated by assays based on different antioxidant mechanisms of action, i.e., with •OH, DPPH• and ABTS•+ radicals as well as CUPRAC (cupric ions reducing power) and lipid peroxidation inhibition assays. The pro-oxidant property of compounds was measured as the rate of oxidation of Trolox. The Mg(II) and Mn(II)/Na(I) complexes with isoferulic acid showed higher antioxidant activity than ligand alone in DPPH (IFA, IC50 = 365.27 μM, Mg(II) IFA IC50 = 153.50 μM, Mn(II)/Na(I) IFA IC50 = 149.00 μM) and CUPRAC assays (IFA 40.92 μM of Trolox, Mg(II) IFA 87.93 μM and Mn(II)/Na(I) IFA 105.85 μM of Trolox; for compounds’ concentration 10 μM). Mg(II) IFA is a better scavenger of •OH than IFA and Mn(II)/Na(I) IFA complex. There was no distinct difference in ABTS•+ and lipid peroxidation assays between isoferulic acid and its Mg(II) complex, while Mn(II)/Na(I) complex showed lower activity than these compounds. The tested complexes displayed only slight antiproliferative activity tested in HaCaT human immortalized keratinocyte cell line within the solubility range. The Mn(II)/Na(I) IFA (16 μM in medium) caused an 87% (±5%) decrease in cell viability, the Mg salt caused a comparable, i.e., 87% (±4%) viability decrease in a concentration of 45 μM, while IFA caused this level of cell activity attenuation (87% ± 5%) at the concentration of 1582 μM (significant at α = 0.05).

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“…Antioxidant activity test by DPPH method was performed according to a previous method used by others [21][22][23][30][31][32]. Briefly, the compounds to be tested were dissolved in methanol at concentrations of 2; 4; 8; 16, and 32 μM.…”

Section: Antioxidant Activity Testmentioning

confidence: 99%

“…In this study, we aimed to determine the chemical reactivity of the organotin(IV) carboxylate compounds diphenyltin(IV) di-4-aminobenzoate and triphenyltin(IV) 4-aminobenzoate by using cyclic volta-mmetry. We also examined the antioxidant properties of these compounds using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method using a similar procedure applied by others [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

The Chemical Reactivity Study of Organotin(IV) 4-aminobenzoates Using Cyclic Voltammetry and Antioxidant Activity Test by the DPPH Method

Sari¹,

Qudus²,

Hadi³

2020

Rev. Chim.

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Chemical reactivity studies of the organotin(IV) carboxylates diphenyltin(IV) di-4-amino-benzoate (1) and triphenyltin(IV) 4-aminobenzoate (2) were conducted using cyclic voltammetry. Then, their antioxidant activities were tested by the 2,2-diphenyl-1-picrylshydrazyl (DPPH) method. Cyclic voltammetry was used to determine the kinetic constants of compounds 1 and 2 for the forward chemical reaction (kf). The constant values of the chemical reaction rate of 1 and 2 on cyclic voltammogram by experiment were obtained by comparing with the values from digital simulation methods obtained using Polar software 5.8.3. The results demonstrated that the constant value of the rate of the subsequent chemical reaction is a function of the rate of its potential (slope = kf/i); that is, 6.481 and 6.069 1/V for 1 and 2, respectively. The type of chemical reaction mechanism that occurs around the surface of the working electrode follows reaction mechanism of electrochemical reaction is quasi reversible and chemical reaction is irreversible (EqCi). The antioxidant activities of compounds 1 and 2 produced IC50 values of 5.91 and 12.57 ig/mL, respectively. These results indicate that both compounds are active as antioxidants. However, their antioxidant activities were lower than that of ascorbic acid, which has an IC50 value of 0.66 ig/mL.

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Synthesis, Characterization and Antioxidant Activity of Cooper-Quercetin Complex and Iron-Quercetin Complex

Cited by 8 publications

References 9 publications

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

Crystal Structure, Spectroscopic Characterization, Antioxidant and Cytotoxic Activity of New Mg(II) and Mn(II)/Na(I) Complexes of Isoferulic Acid

The Chemical Reactivity Study of Organotin(IV) 4-aminobenzoates Using Cyclic Voltammetry and Antioxidant Activity Test by the DPPH Method

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