Synthesis, characterization and antimicrobial screening of hybrid molecules containing benzimidazole-pyrazole and pyridine nucleus

Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents

“…After workup and purification with column chromatography (20% EtOAc in hexane as eluent), compound 18c (1.05 g, 3.78 mmol) was obtained in 95% yield as yellow solids: 1 H-NMR (acetone- d 6 , 500 MHz) δ 3.90 (s, 3 H, OCH 3 ), 7.08 (d, J = 9.0 Hz, 2 H, 2 × ArCH), 7.35 (t, J = 7.5 Hz, 1 H, ArCH), 7.42 (t, J = 7.5 Hz, 1 H, ArCH), 7.68 (d, J = 8.5 Hz, 1 H, ArCH), 7.84 (d, J = 9.0 Hz, 2 H, 2 × ArCH), 7.87 (d, J = 8.0 Hz, 1 H, ArCH), 7.99 (d, J = 16 Hz, 1 H, COCH), 8.04 (d, J = 16 Hz, 1 H, PhCH); 13 C-NMR (acetone- d 6 , 125 MHz) δ 55.97, 113.59, 115.56, 120.09, 122.37, 124.08, 126.63, 128.45, 131.72, 135.76, 144.73, 145.21, 150.44, 163.29, 181.81; IR (neat) 3357 (s), 3192 (N–H, s), 2920 (s), 2850 (s), 2313 (w), 1756 (br), 1657 (C=O, s), 1634 (s), 1586 (C=N, m), 1514 (m), 1468 (m), 1421 (m), 1369 (w) 1322 (C–N, w) 1243 (s), 1172 (m), 1089 (w), 1056 (w), 823 (w), 718 (w), 631 (w); MS (ESI) m/z calcd for C 17 H 14 N 2 O 2 : 278.1055, found: 278.1055. Its spectroscopic characteristics are consistent with those reported for the same compound [56].…”

“…Compound 18a–18d had been reported in previous literatures [56]. Aqueous KOH (40%) was added to a stirred solution of 2-acetylbenzimidazole ( 17 , 1.0 equiv) and substituted aromatic aldehydes (1.1 equiv) in ethanol.…”

Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity

“…Earlier our research group has synthesized different heterocyclic derivatives as potential antimicrobial agents [29][30][31][32][33]. In continuation to this, we synthesized 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(aryl)-4-5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones A series of compounds 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones (4a-q) were synthesized and structures of these compounds were elucidated by spectral (IR, 1 H NMR, 13 C NMR, mass spectra) analysis.…”

Hybrid Approach for Synthesis and Antimicrobial Activity of Heterocyclic Compounds

“…Encouraged by the above-mentioned explanation, we have focused onto construct some novel antimicrobial derivatives containing pyrazole, 1,3,4-oxadiazole and pyridine scaffolds screened for antimicrobial activity. Previously our research group has worked on the synthesis of pyrazole and their derivatives as potential antimicrobials [22][23][24]. In furtherance to this, N- (…”