Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

“…The model reaction and yields are shown in Scheme 1 and Table 1. Eight candidates such as trypsin from porcine pancreas (PPT), α-amylase from hog pancreas, diastase from Aspergillus oryzae, α-amylase from Aspergillus oryzae, lipase AT30, Amano lipase M from Mucor javanicus, and bovine serum albumin (BSA) were screened ( Table 1, entries [1][2][3][4][5][6][7][8]. The yield of product was the monitored parameter to evaluate the catalytic activity of enzymes.…”

“…Thiazoles and their derivatives are an important class of heterocyclic compounds which possess broad biological activities, such as antimicrobial [1], antipyretic [2], antiparasitic [3], antihistaminic [4], and antiviral properties [5]. Aryl-substituted thiazoles are also important functional materials in applications such as fluorescent dyes and liquid crystals [6].…”

Crystal structure of (E)-5-((4-chlorophenyl)diazenyl)-2-(5-(4-fluorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazole, C23H17ClFN5S2

“…Compounds bearing thiazole and pyrazole nuclei are found to have various antimicrobial activities such as antibacterial, antifungal and antitumor [1][2][3][4][5][6][7]. The asymmetric unit (cf.…”

Optimized Synthesis of Novel Pyrazole Based Thiazole Derivatives and their Antimicrobial Evaluation

“…3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (1) was prepared according to the literature method [34].…”