Hybrid Approach for Synthesis and Antimicrobial Activity of Heterocyclic Compounds

Abstract

Abstract. We have synthesized novel series of N- (1-(2-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethylidene)arylaniline and their derivatives. The structures of synthesized compounds were well characterized by spectroscopic techniques. Antimicrobial activity of the newly synthesized derivatives was evaluated against gram positive (S. aureus and S. pyogenes), gram negative bacteria (E. coli and P. aeruginosa), and strains of fungi (C. albicans, A. niger and A. clavatus). Among the screened derivatives 5c, 5f, 5i, 5l and 5t demonstrated superior antimicrobial activity against microbial strains.

A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

“…Interesting biological activities are associated with pyrazole derivatives such as anti-tubercular, [2] antimicrobial, [3] anti-consultant, [4] anticancer, [5] anti-viral, [6] and so forth. Pyrimidinthione derivatives are very important in pharmaceutical and medicinal chemistry as they showed wide range of biological activities.…”