Synthesis, Characterization and Antibacterial Activity of Cobalt(iii) Complex With Phenanthroline and Maltose

Abstract

The mononuclear cobalt(III) complex derived from 1,10-phenanthroline and maltose ([Co(phen) 2 maltose]Cl 2 •3H 2 O) (1) has been synthesized and characterized in aqueous solution. Its characterization was based on its optical and spectroscopic properties.The antimicrobial activity of this complex was screened in vitro against the microorganisms Escherichia coli DH5a, Salmonella enterica sv Enteritidis ISP/953, Klebsiella pneumoniae RYC492, Pseudomonas aeruginosa PAO1, Enterococcus faecalis ATCC 29212, Bacillus cereus GCA234, Micrococcus sp. Staphylococcus aureus ATCC25923.Complex (1) showed antibacterial activity with a bacteriostatic effect over Gram positive and negative bacteria. The cytotoxicity of complex (1) was tested in vitro on human embryonic kidney cells.Keywords: Carbohydrate-cobalt(III) complexes; circular dichroism; antibacterial activity.e-mail: jparada@ciq.uchile.cl INTRODUCTIONTransition metal complexes are of interest since they display a wide variety of application in fields ranging from materials science and catalysis to biological activity [1].From the biological point of view, several studies have shown that the complexes may have antibacterial, antifungal and antitumor activity [2].The biological activity of metal complexes is highly dependent on the nature of the metal ions and the donor sequence of the ligands because different ligands exhibit different biological properties [3].An interesting group of ligands are the carbohydrates [4], whose complexes have shown significant antimicrobial activity against Gram-positive and Gramnegative bacterial strains as well as a few fungal strains [5]. Poller and Parkin reported the synthesis of organometallic derivatives of sucrose (lead, tin and germanium). In that study organotin was found to exhibit higher biocidal activities than would be expected from the tin content [6].A few sugar-cobalt complexes with antibacterial activity have been reported. An important example is grafted PVA polymer with a derivative of erythro-ascorbic acid (pentulosono-lactone-2,3-enedianisoate) reported by Salih et al. It was evaluated for antimicrobial properties against four pathogenic bacteria (Escherichia coli, Klebsiella pneumonae, Staphylococcus aureus, Staphylococcus albus) and fungi (Aspergillus niger, yeast). This cobalt complex showed good activity against the various microbial isolates [7].1,10-Phenanthroline is also one of the biologically important ligands, and several studies show that this ligand and a number of its complexes are effective against various strains of microorganisms. Here the synthesis of the mixed ligand cobalt complex [Co(phen) 2 maltose] Cl 2 ·3H 2 O (1), as well as its spectral features and optical activity are reported.UV-visible absorption spectroscopy and circular dichroism spectroscopy allow us to assign a D configuration to complex (1).The complex was also screened for antibacterial activity against Gram positive and Gram-negative bacteria. We determined the antibacterial effects and evaluated their cytotoxic effect on h...

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

“…Due to the importance of metal NPs in the anticancer and antibacterial activities, special attention should be paid to optimizing their production with uniformed size and shapes. Numerous studies have been conducted to control the synthesis of Co 3 O 4 NPs, [51][52][53] and the present study is highly consistent with the previous results. Herein, the XRD pattern results show that Co 3 O 4 NPs are well crystallized which is consistent with the previous models of Liang et al, 54 Khan et al, 52 Chattopadhyay et al, 55 and Rahimi-Nasrabadi et al 50 The pattern illustrates the pure structure of Co 3 O 4 NPs synthesized by the sol-gel method.…”

“…Similar to our results, previous studies have reported the antibacterial activities of copper oxide, 66,67 cerium oxide, 62 zinc oxide 68,69 and zero-valent iron 38 NPs. In addition, Chang et al, 70 Parada et al 53 and Khan et al 52 showed that by increasing the concentration of Co 3 O 4 NPs up to 200 µg/mL., the activity of both Gram-positive and Gram-negative bacteria were significantly decreased. It has also been observed that the synthesis of Co 3 O 4 -cellulose magnetic 71 and graphene-Co 3 O 4 72 nanocomposites not only drastically reduce the activity of Gram-positive bacteria, but also they increase the antibacterial activity of cobalt by several times against Gram-negative bacteria.…”

Antibacterial Activity and Human Cell Cytotoxic of Cobalt (Iii) Complexes With 1,10-Phenanthroline and Carbohydrate Ligands

“…These results suggest that the presence of carbohydrates as ligands in the complexes reduces cytotoxicity against human kidney embryonic cells, which is consistent with the results previously obtained for complexes with maltose or arabinose [43].…”

“…The UV-VIS absorption and CD spectra of (1) are consistent with those reported earlier for [Co(phen) 2 L]Cl 2 , where L=sucrose or maltose [42,43].…”

Synthesis, characterization and biological properties of mixed ligand complexes of cobalt(II/III) valproate with 2,9‐dimethyl‐1,10‐phenanthroline and 1,10‐phenanthroline

“…Single bacterial colonies were dissolved in the sterile saline until the turbidity of the suspended cells reached the McFarland 0.5 Standard then the bacterial inoculate were spread on the surface of the Muller Hinton nutrient agar by using a sterile cotton swab. After that, the wells (6 mm in diameter) in the agar plate were made by using a sterile glass borer …”