“…Similarly, Co (II), Ni (II), Cu (II), Zn (II), Cd (II), and Hg (II) metal complexes with benzofuran derivative combines with Schiff bases, namely (E)-7-methoxy-N1-(2,4,5-trimethoxy benzylidene) benzofuran-2-carbohydrazide and (E)-N1-(2,6-dichloro benzylidene)-7-methoxy benzofuran-2-carbohydrazide which are reactive against Staphylococcus aureus , Staphylococcus citreus , Bacillus polymyx , Bacillus cereus , and Lactobacillus and Gram-negative species Proteus mirabilis , Klebsiella pneumonia , E. coli , Salmonella typhi , and Pseudomonas aeruginosa . Shiff's bases act as a chelating agent, and these heterocyclic rings of C=N bonds with the N 2 and O 2 donor system inhibit the enzymatic activity of bacteria [ 107 ]. The antibacterial activity is reported to be associated with the terpolymers of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde against Shigella sonnei , Escherichia coli , Klebsiella species, Staphylococcus aureus , Bacillus subtilis , and Salmonella typhimurium [ 108 ].…”