Synthesis, Characterization, and Antibacterial Activity of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) Complexes of Schiff's Base Type Ligands Containing Benzofuran Moiety

Abstract

Six new complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) with substituted benzofuran derivatives have been synthesized and characterized by elemental analysis, magnetic moments, conductance measurements, spectral characterization, and so forth. Elemental data coincide with the general formula MLC1n, where L = (E)-7-Methoxy-N1-(2,4,5-trimethoxy benzylidene) benzofuran-2-carbohydrazide (L1) or (E)-N1-(2,6-dichloro benzylidene)-7-methoxy benzofuran-2-carbohydrazide (L2), of the complexes. The ligands coordinate to the metal ions through the oxygen of the carbonyl group and the nitrogen of the hydrazine group. Electronic spectral data of the complexes suggests the probable geometry is octahedral in nature. All the complexes and ligands were screened for their antibacterial activity. Among them, Co, Ni, and Cu complexes of L2 showed good activity against all microbes.

Molecular Docking, Antimicrobial, Anticancer Effect of Schiff Base Ligand and Its Co (II), Ni (II), Cu (II) and Cd (II) Complexes

“…Such enhanced activity might be due to better binding a nity of Cobalt (II) complex of L 2 with proteins. Similar to our reports [10] have also been noticed for their Cobalt (II) complex containing Benzofuran moieties. Nickel (II) complex of ligand (L) forms three hydrogen bonds with the protein in residues of Glu292 Å, Lys 199 Å and Gln196 Å with bond distances of 3.20 Å, 3.17 Å and 3.14 Å respectively.…”

Synthesis, spectral characterization and antimicrobial effect of Cu(II) complexes of schiff Base Ligand, N-(3,4- dimethoxybenzylidene)-3-aminopyridine (DMBAP) Derived from 3,4-dimethoxybenzaldehyde and 3-aminopyridine

“…Two bands are in the region of 595 nm [16807 cm -1 ] and 560 nm [17857 cm -1 ] of electronic spectra of Cu(II) complexes may be due to 2 E g → 2 T 2g transitions, respectively, indicating octahedral geometry Silversteins et al, 1976) for Cu-complex. Further supported (Reddy et al, 2013) by high μ eff value in the range of 2.04 and 1.92, respectively, (Hermle et al, 2011) show paramagnetic nature. Molar conductance of the complexes were measured in solvent DMSO and all the complexes were found to be non-electrolytic in nature (Ahmed et al, 2011) and the conductivity are in the range of 24 and 20 mho cm 2 mol -1 or S cm 2 mol -1 (Table 3).…”

Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects

“…Similarly, Co (II), Ni (II), Cu (II), Zn (II), Cd (II), and Hg (II) metal complexes with benzofuran derivative combines with Schiff bases, namely (E)-7-methoxy-N1-(2,4,5-trimethoxy benzylidene) benzofuran-2-carbohydrazide and (E)-N1-(2,6-dichloro benzylidene)-7-methoxy benzofuran-2-carbohydrazide which are reactive against Staphylococcus aureus , Staphylococcus citreus , Bacillus polymyx , Bacillus cereus , and Lactobacillus and Gram-negative species Proteus mirabilis , Klebsiella pneumonia , E. coli , Salmonella typhi , and Pseudomonas aeruginosa . Shiff's bases act as a chelating agent, and these heterocyclic rings of C=N bonds with the N 2 and O 2 donor system inhibit the enzymatic activity of bacteria [ 107 ]. The antibacterial activity is reported to be associated with the terpolymers of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde against Shigella sonnei , Escherichia coli , Klebsiella species, Staphylococcus aureus , Bacillus subtilis , and Salmonella typhimurium [ 108 ].…”