Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Abstract

Um quimiossensor potenciométrico para determinação seletiva de sertralina foi desenvolvido, baseado na técnica de impressão molecular. O polímero impresso molecularmente foi sintetizado através da polimerização por precipitação, usando hidrocloreto de sertralina como molécula molde, ácido metacrílico como monômero funcional e dimetacrilato de etileno glicol como um agente de ligação cruzada. O sensor foi desenvolvido pela dispersão das partículas de polímero impressas na sertralina, em plastificante dibutil sebacato e incorporação em matiz de poli(cloreto de vinila). As características do sensor proposto foram avaliadas medindo a resposta do potencial para hidrocloreto de sertralina, no intervalo de 1,0 µmol L -1 a 10 mmol L -1 com resposta Nernstiniana de 57,7 mV década -1 e um limite de detecção de 0,8 µmol L -1 . Os coeficientes de seletividade potenciométrica do sensor proposto foram avaliados e exibiram boa seletividade para sertralina com relação a outros antidepressivos. Foi usado como eletrodo indicador na determinação potenciométrica de sertralina em comprimidos e fluidos biológicos.A potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 µmol L -1 to 10 mmol L -1 with a near Nernstian response of 57.7 mV decade -1 and a limit of detection of 0.8 µmol L -1 . The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids.

La2O3/Co3O4 nanocomposite modified screen printed electrode for voltammetric determination of sertraline

“…These values were compared with values reported by other research groups for electrochemical determination of sertraline (Table I). 7,[17][18][19] With respect to Table I, the linear dynamic range (LDR) and the detection limit of (LOD) present work are comparable to values acquired by other research groups.…”

“…[13][14][15] However, because of the poor electrochemical behaviour of the most of electro--active analytes, low reducibility, sensitivity and high over potential at electrodes, the performance of the electrodes in electrochemical methods can be improved if they were modified by various nanomaterials and methodologies. [16][17][18][19][20][21][22][23][24][25][26][27] Nanostructured materials are one of the most promising supporting materials for surface modification of electrodes, due to their unique properties, such as good biocompatibility, high surface-to-volume ratio, substantial mechanical power and electrical properties. Lanthanum (La) is one of the most important lanthanide elements.…”

Surface morphology changes of polymer membrane and carbon paste sertraline sensors

“…It is less expensive than methods [2,3]. It is characterized by wide linear range and low LOD and near Nernastian value, 59.60 mV/decade, than that in case of the method [1] in Table 4, thus proving that it is a good Ser-ion selective sensor for the pure and pharmaceutical preparations with high accuracy and precision.…”

“…Potentiometric chemo sensors for selective determination of sertraline based on the molecular imprinting technique and electrometric methods using voltammetric technique were developed [1][2][3]. Several spectroscopic methods have been reported for the determination of Ser + and their metabolites in pharmaceutical formulation [4][5][6].…”

Azithromycin-molecularly imprinted polymer based on PVC membrane for Azithromycin determination in drugs using coated graphite electrode

“…Several papers were published concerning electrodes preparation based on drug molecular imprinted polymer in PVC matrix membranes, a PVC membrane based on metoprolol-MIP using graphite electrode [6], solid-state ISE based on molecular imprinted polymer and graphite electrode [7], diphenylamine [8], hydroquinone [9], aspirin [10], ascorbic acid [11], sertraline [12] and ciprofloxacin [13]. Several ionic imprinted polymers (IIP) were published such as; cadmium IIP [14], iron [15], dysprosium (III) [16] and thorium (IV) [17].…”