Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro

Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde

“…The spectra revealed the presence of -CH=N group around δ 158.01 ppm. The signal at δ 176.47 ppm due to C-OH [8]. These spectra data sports the structure of synthesized compound.…”

“…The cross peak at δH/δC = 8.39/158 ppm due to azomethine group (CH=N). Thus, the correlation of protons and carbon in aromatic rings such as, δH/δC = 7.57/137, 7.48/129 ppm and other positions can be assigned to the protons and carbon atoms of the aromatic rings [8], while the cross peak at δH/δC = 3.73/54.7 and δH/δC = 2.93/37.4 ppm can be attributed to methylene groups, Figures 1 and 2.…”

Computational and experimental insight into antituberculosis agent, (E)-benzyl-2-(4-hydroxy-2-methoxybenzylidene) hydrazinecarbodithioate: ADME analysis

“…SBDTC Schiff bases can form cis-trans and trans-cis isomers due to the N–C and C–S bond and they have significant versatile coordination character and biological activities [ 6 , 7 , 8 , 9 ]. An imine group (–RC = N–) containing Schiff bases are also used as dyes, intermediate reactants in the synthesis of organic compounds, catalysts, stabilizing agent in polymeric products, chelating agents in analytical separation methods and inhibitor of corrosion [ 10 , 11 ]. Moreover, Schiff bases possess noteworthy applications in multifaceted areas such in the solar cell, optical ingredients [ 6 , 7 , 9 , 12 ] and medication area such as antiviral, antifungal, antibacterial, insecticidal, anti-HIV, anticancer, antiprotozoal, antimalarial, anti-inflammatory, antidiabetic and antitumor [ 2 , 3 , 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

“…An imine group (–RC = N–) containing Schiff bases are also used as dyes, intermediate reactants in the synthesis of organic compounds, catalysts, stabilizing agent in polymeric products, chelating agents in analytical separation methods and inhibitor of corrosion [ 10 , 11 ]. Moreover, Schiff bases possess noteworthy applications in multifaceted areas such in the solar cell, optical ingredients [ 6 , 7 , 9 , 12 ] and medication area such as antiviral, antifungal, antibacterial, insecticidal, anti-HIV, anticancer, antiprotozoal, antimalarial, anti-inflammatory, antidiabetic and antitumor [ 2 , 3 , 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 ]. From the point of view, we report herein the synthesis, characterization as well as investigation of in silico quantum calculations of the entitled SBDTC Schiff base in particulars.…”

Synthesis, in vitro Antimicrobial assay and Molecular Docking Studies of some new Symmetrical Bis-Schiff Bases and their 2-Azetidinones.

“…Symmetrical bis-azomethines (Ar-N=CH-Ar-CH=N-Ar) have a similar synthetic mono Schiff b e' p hw y bu by u ing he different molar ratio (Ozdemir Gungor, 2017). Schiff bases have broad variability applications in a medicinal field that possess a wide spectrum of biological activities such as antibacterial (Ziwar and Musheer), antioxidant (Hassan, 2019), antifungal (Noori et al, 2019), anti-inflammatory, ZANCO Journal of Pure and Applied Sciences 2021 analgesic, anticancer (Kajal et al, 2013), antitumor (Ibrahim, 2015), anticonvulsant antimalarial, anti-tubercular (Khdur and Zimam, 2018a), and antidiabetic (Al-Masoudi et al, 2016).…”